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Table 5 Sedative consumption and differences between periods a

From: Evaluation of a minimal sedation protocol using ICU sedative consumption as a monitoring tool: a quality improvement multicenter project

  Preintervention Postintervention   
  October 2010 to September 2011 October 2011 to October 2012 Mean difference (95% CI) P-value
Monthly average midazolam consumption (mg) 21,825 ± 3,835 8,297 ± 5,628 -13,528 (-17,548; -9,508) <0.001
Average midazolam consumption per day of MV (mg/day) 329 ± 70 163 ± 115 -167 (-246; -87) <0.001
Monthly average propofol consumption (mg) 36,210 ± 12,506 40,297 ± 10,459 4,088 (-5,422; 13,598) 0.383
Average propofol consumption per day of MV (mg/day) 541 ± 190 779 ± 210 238 (72; 404) 0.007
Monthly average fentanyl consumption (μg) 30,021 ± 9,029 19,057 ± 4,302 -10,964 (-16,670; -5,258) 0.001
Average fentanyl consumption per day of MV (μg/day) 458 ± 170 370 ± 90 -88 (-202; 25) 0.120
Monthly average dexmedetomidine consumption (μg) 4,350 ± 1,592 5,186 ± 2,066 836 (-700; 2,372) 0.272
Average dexmedetomidine consumption per day of MV (μg/day) 65 ± 20 100 ± 40 35 (07; 62) 0.017
Monthly average haloperidol consumption (mg) 176.4 ± 24 195.0 ± 61 18.7 (-20.0; 57.5) 0.328
Average haloperidol consumption per day of MV (mg/day) 03 ± 0.5 04 ± 1.0 1.1 (0.4; 1.7) 0.002
  1. aMV, Mechanical ventilation.