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Table 4 Characteristics of the mechanically ventilated patients a

From: Evaluation of a minimal sedation protocol using ICU sedative consumption as a monitoring tool: a quality improvement multicenter project

 

Preintervention (n= 2,446)

Postintervention (n= 2,405)

P-value

Characteristics

October 2010 to September 2011

October 2011 to October 2012

 

Age, yr, mean ± SD

62.37 ± 19

61.99 ± 18

0.467

Male, n (%)

1,306 (53.4)

1,275 (53.0)

0.792

BMI, kg/m2, mean ± SD

26.7 ± 6

26.7 ± 6

0.726

SAPS III score, mean ± SD

52.65 ± 19

51.44 ± 20

0.031

Charlson index score, median (IQR)

1 (0; 2)

1 (0; 2)

0.181

Admission type, n (%)

  

0.119

Medical

1,547 (63.2)

1,452 (60.4)

 

Elective surgical

767 (31.4)

811 (33.7)

 

Emergency surgical

132 (5.4)

142 (5.9)

 

Diagnosis category, n (%)

  

Cardiovascular

219 (9.0)

208 (8.6)

0.708

Sepsis

505 (20.6)

548 (22.8)

0.071

Neurological

284 (11.6)

276 (11.5)

0.883

Respiratoryb

303 (12.4)

182 (7.6)

<0.001

Orthopedic surgery

28 (1.1)

31 (1.3)

0.647

Neurosurgery

63 (2.6)

47 (2.0)

0.146

Thoracic surgery

24 (1.0)

31 (1.3)

0.311

Cardiac surgery

545 (22.3)

627 (26.1)

0.002

Resources during ICU, n (%)

  

RRT

174 (7.1)

185 (7.7)

0.441

Vasopressors

1,321 (54)

1,436 (59.7)

<0.001

Noninvasive ventilation

639 (26.1)

612 (25.4)

0.590

Mechanical ventilation, n (%)

  

During ICU stay

2,446 (100)

2,405 (100)

-

At ICU admission

1,677 (68.6)

1,673 (69.6)

0.450

Tracheotomy

314 (12.8)

237 (9.9)

0.001

Length of mechanical ventilation

  

Mean ± SD

3.91 ± 6.2

3.15 ± 4.6

<0.001

Median (IQR)

1 (1; 4)

1 (1; 3)

0.001

MV >24 hr

1,007 (41.1)

971 (40.2)

0.510

28 ventilator-free days

   

Mean ± SD

16.07 ± 12.2

18.33 ± 11.6

<0.001

Median (IQR)

24 (0; 27)

26 (0; 27)

<0.001

ICU LOS, days

   

Mean ± SD

8.87 ± 11.9

7.46 ± 9.2

<0.001

Median (IQR)

5 (2; 12)

4 (2; 10)

<0.001

Total hospital LOS, days

   

Mean ± SD

23.75 ± 33.7

23.80 ± 31.3

0.961

Median (IQR)

13 (6; 28)

13 (6; 27)

0.707

Mortality, % (95% CI)

   

ICU mortality

36.8% (35.0; 38.8)

29.6% (27.8; 31.4)

<0.001

Hospital mortality

45.4% (43.5; 47.4)

38.1% (36.2; 40.1)

<0.001

  1. aBMI, Body mass index; ICU, Intensive care unit; MV, Mechanical ventilation; RRT, Renal replacement therapy. bRespiratory diagnosis except pneumonia.