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Table 3 Characteristics of overall cohort a

From: Evaluation of a minimal sedation protocol using ICU sedative consumption as a monitoring tool: a quality improvement multicenter project

  Preintervention (n= 11,256) Postintervention (n= 11,709) P-value
Characteristics October 2010 to September 2011 October 2011 to October 2012  
Age, yr, mean ± SD 59.62 ± 19 59.53 ± 19 0.714
Male, n (%) 5,705 (50.7) 5,924 (50.6) 0.891
BMI, kg/m2, mean ± SD 26.9 ± 6 27.1 ± 6 0.055
SAPS III score, mean ± SD 42.49 ± 15 42.06 ± 15 0.027
Charlson index score, median (IQR) 1 (0; 2) 1 (0; 2) 0.106
Admission type, n (%)    0.021
Medical 8,399 (74.6) 8,549 (73.0)  
Elective surgical 2,547 (22.6) 2,285 (24.1)  
Emergency surgical 310 (2.8) 333 (2.8)  
Diagnosis category, n (%)    
Cardiovascular 3,390 (30.1) 3,480 (29.7) 0.512
Sepsis 1,386 (12.3) 1,653 (14.1) <0.001
Neurological 1,376 (12.2) 1,336 (11.4) 0.056
Respiratoryb 778 (6.9) 645 (5.5) <0.001
Orthopedic surgery 733 (6.5) 814 (7.0) 0.184
Neurosurgery 218 (1.9) 267 (2.3) 0.070
Thoracic surgery 89 (0.8) 99 (0.8) 0.645
Cardiac surgery 625 (5.6) 706 (6.0) 0.122
Resources during ICU, n (%)   
RRTc 410 (3.6) 414 (3.5) 0.665
Vasopressorsc 1,838 (16.3) 2,055 (17.6) 0.013
Noninvasive ventilationc 1,735 (15.4) 1,314 (11.2) <0.001
Mechanical ventilation, n (%)   
During ICU stay 2,446 (21.7) 2,405 (20.5) 0.027
At ICU admission 1,677 (14.9) 1,673 (14.3) 0.190
ICU LOS, days    
Mean ± SD 4.20 ± 6.5 3.87 ± 5.3 <0.001
Median (IQR) 2 (1; 4) 2 (1; 4) 0.095
Total hospital LOS, days    
Mean ± SD 13.29 ± 22.6 12.94 ± 20.1 0.215
Median (IQR) 7 (4; 14) 7 (4; 14) 0.110
Mortality, % (95% CI)    
ICU mortality 9.5% (9.0; 10.0) 7.3% (6.8; 7.7) <0.001
Hospital mortality 14.1% (13.5; 14.8) 11.9% (11.3; 12.5) <0.001
  1. aBMI, Body mass index; ICU, Intensive care unit; LOS, Length of stay; MV, Mechanical ventilation; RRT, Renal replacement therapy; SAPS III, Simplified Acute Physiology Score III. bRespiratory diagnosis except pneumonia. cData were missing for two patients.