Diagnosing external ventricular drain-related ventriculitis by means of local inflammatory response: soluble triggering receptor expressed on myeloid cells-1

Table 4 Sensitivity, specificity, positive predictive value, and negative predictive value of diagnostic tests in the diagnosis of external ventricular drainage-related ventriculitis

Variable	AUC	Optimum cut-off point	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	LR +	LR-
Temperature (°C)	0.699	37.7	83.3	65.7	17.86	97.78	2.43	0.25
Serum PCT (ng/ml)	0.7	0.165	75	52	10.71	96.43	1.56	0.48
Serum CRP (mg/dl)	0.674	59	66.7	44.4	7.41	95.24	1.20	0.75
Serum leucocytes (mm³)	0.580	15,000	66.7	74.2	19.05	96.08	2.49	0.45
CSF leucocytes (mm³)	0.904	1,320	80	83.9	30.77	97.72	4.98	0.24
CSF neutrophils (mm³)	0.864	1,041	80	83	33.33	97.50	4.70	0.24
CSF glucose (mg/dl)	0.996	28.5	100	98.2	83.33	100	55	-
CSF proteins (mg/dl)	0.918	267.6	100	87.5	41.67	100	8	-
CSF sTREM-1 (pg/ml)	0.995	2,388.79	100	98.5	85.71	100	66	-

AUC, area under curve; CRP, C-reactive protein; CSF, cerebrospinal fluid; LR +, positive likelihood ratio; LR-, negative likelihood ratio; NPV, negative predictive value; PCT, procalcitonin; PPV, positive predictive value; sTREM-1, soluble triggering receptor expressed on myeloid cells-1.

ISSN: 1364-8535