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Table 3 The effect of changing creatinine clearance on mean (50 th percentile) and 10 th percentile trough concentrations from the simulated ECMO patients (n = 1,000) receiving various meropenem doses

From: The combined effects of extracorporeal membrane oxygenation and renal replacement therapy on meropenem pharmacokinetics: a matched cohort study

    Dose  
Creatinine clearance Concentration percentile 500 mg 8-hrly 1 g 8-hrly 2 g 8-hrly
20 50th 18.9 26.4 76.4
  10th 3.6 16.2 14.6
50 50th 14.5 19.7 58.8
  10th 2.6 9.8 10.5
80 50th 10.0 14.8 39.7
  10th 1.3 4.8 5.1
120 50th 7.6 11.1 30.0
  10th 0.7 2.5 2.7
180 50th 5.6 7.9 21.7
  10th 0.4 0.7 0.9
  1. These simulations assume that no significant accumulation of meropenem occurred in study population. ECMO, extracorporeal membrane oxygenation.