Controls | ECMO | |||
---|---|---|---|---|
No RRT | RRT | No RRT | RRT | |
(n = 5) | (n = 5) | (n = 6) | (n = 5) | |
Male/Female | 3/2 | 3/2 | 1/5 | 3/2 |
Age (years) | 55.0 (48–61) | 56 (46–66) | 29 (16–46) | 38 (23–56) |
Total body weight (kg) | 80 (75–85) | 70 (60–100) | 69 (60–80) | 70 (70–76) |
Mechanical ventilation | 5/5 | 5/5 | 5/5 | 5/5 |
Type of ECMO (VA/VV) | 0/0 | 0/0 | 3/3 | 2/3 |
Day 1 SOFA score | 3 (3–4) | 15 (14–16) | 9 (7–14) | 16 (13–17) |
Plasma creatinine concentration (μmol/L) | 73 (55–101) | na* | 75 (44–82) | na* |
Creatinine clearance (mL/min) | 106 (98–127) | na* | 108 (65–183) | na* |
RRT mode | - | CVVH | - | EDD-f |
Serum bilirubin (μmol/L) | 9 (5–23) | 93 (36–115) | 23 (9–73) | 58 (34–134) |
Serum albumin (g/L) | 22 (18–36) | 26 (23–36) | 31 (27–35) | 24 (22–32) |
Serum proteins (g/L) | 56 (55–70) | 62 (60–65) | 49 (46–54) | 44 (34–56) |
Meropenem daily dose (g) | 1 q 8 h | 1 q 8 h | 1 q 8 h | 1q 8 h |
Plasma C max (mg/L) | 93 (74–119) | 58 (52–68) | 42 (27–56) | 59 (50–86) |
Plasma C min (mg/L) | 0 (0–2) | 7.5 (5–18) | 4.9 (2–10) | 18 (7–43) |