Skip to main content
Figure 1 | Critical Care

Figure 1

From: Multi-scale symbolic entropy analysis provides prognostic prediction in patients receiving extracorporeal life support

Figure 1

The first operation of MSsE is coarse graining. We divide the time series {x1, x2 … xM} into non-overlapping boxes of size N (scale "N"). The median of each local box is taken, thus producing a new time series y 1 N , y 2 N … y k N . The second stage in forming the sign time series is to transform the coarse-grained series into yet another new series by taking the directions in its change. We measure the change against a threshold value and acquire the sign series b 1 N , b 2 N … b k N , where b i N is either +1 or -1, depending on whether the corresponding y i N is increasing or decreasing. To quantify the complexity of the sign sequence, we sort all sequences into categories of sub-sets consist of L consecutive binary bits (L-bit; L = 8 in this study). The probability distribution of all patterns of sub-sets is recorded. To avoid over-counting similar patterns, the data sequence of total length L should be divided into multiple m-dimensional vectors; each consists of m consecutive bits {(b1, b2, … bm); (b2, b3, … bm +1); …}. The conditional probability is determined numerically by the ratio of number of each paired vectors which are of exactly same binary codes for dimension "m+1" to the number for the identical vectors of dimension "m". By identifying the patterns of the same conditional probability, it allows us to rank the m-bit patterns according to the information they imply (large rank number means lower conditional probability). The expectation value of the rank conceptually indicates the degree of uncertainty.

Back to article page