Table 1 Demographics, perioperative treatments, and outcomes in patients with or without acute kidney injury

Age (years)

67 (65 to 68)

72 (71 to 73)

P <0.001

Male/female (%)

272/147 (64.9/35.1)

108/57 (65.5/34.5)

P =0.98

Height (cm)

172 (170 to 173)

170 (168 to 172)

P =0.02

Weight (kg)

81 (80 to 84)

80 (78 to 83)

P =0.62

Additive Euroscore

4 (4 to 5)

6 (5 to 7)

P <0.001

Preoperative creatinine (μmol/l)

79 (77 to 82)

87 (82 to 94)

P <0.001

Preoperative eGFR ^§ (ml/min/1.73 m2)

83.9 (80.5 to 86.2)

72.6 (67.6 to 78.4)

P <0.001

Preoperative diuretics

Y/N

227/192

103/62

P =0.065

(%)

54.2/ 45.8

62.4/37.6

ScO2 _air (%)

63 (63 to 64)

61 (60 to 62)

P <0.001

ScO2 _ox (%)

68 (67 to 69)

67 (65 to 68)

P =0.005

ScO2 _minox (%)

62 (61 to 62)

59 (57 to 61)

P <0.001

Preoperative LVEF

- good

315 (75.1)

122 (73.9)

P =0.63

- moderate

88 (21)

38 (23)

- poor

16 (3.8)

4 (2.4)

CABG

- no

176 (42)

43 (26.1)

P <0.001

- yes

243 (58)

122 (73.9)

Duration of CPB (min)

110 (104 to 116)

128 (118 to 140)

P <0.001

Duration of surgery

245 (236 to 253)

272 (265 to 288)

P <0.001

Minimal hematocrit (%)

25 (25 to 26)

25 (24 to 25)

P =0.002

Minimal temperature during CBP (°C)

32 (32 to 32)

32 (32 to 32)

P =0.48

Blood products (units)

2 (1 to 2)

3 (2 to 4)

P <0.001

Cristalloids (ml)

4560 (4510 to 4640)

4580 (4450 to 4710)

P =0.84

Colloids (ml)

2000 (2000 to 2500)

2500 (2000 to 2500)

P =0.08

Drainage loss (ml)

800 (800 to 850)

950 (900 to 1000)

P <0.001

Postoperative urine flow (ml/24 h)

2930 (2869 to 3050)

2450 (2198 to 2650)

P <0.001

Postoperative diuretics

Y/N

381/38

145/20

P =0.444

(%)

90.9%/9.1%

87.8%/12.2%

Maximal postoperative lactate (mmol/l)

1.9 (1.7 to 1.9)

2.4 (2.2 to 2.7)

P <0.001

MAP baseline (%)

83 (82 to 85)

85 (82 to 89)

P =0.32

MAP mean IOP (mmHg)

71.7 (71.0 to 72.3)

70.7 (69.5 to 71.7)

P =0.11

CVP mean IOP (mmHg)

10.0 (9.3 to 10.3)

10.7 (10.0 to 11.5)

P =0.006

ScvO2 mean IOP (%)

81.5 (80.6 to 82.0)

80.9 (79.2 to 82.7)

P =0.34

SvO2 mean IOP ^* (%)

79.5 (78.5 to 80.7)

79.3 (77.6 to 80.2)

P =0.74

PAP mean IOP ^* (mmHg)

28.3 (23.5 to 26.2)

26.9 (24.4 to 29.6)

P =0.01

CI mean IOP ^* (l/min/m2)

2.9 (2.8 to 3.1)

1.8 (2.6 to 3.0)

P =0.07

MAP mean POP (mmHg)

75.2 (74.4 to 76.0)

72.6 (71.6 to 74.2)

P <0.001

CVP mean POP (mmHg)

14.7 (14.3 to 14.9)

15.2 (14.8 to 16.2)

P <0.001

ScvO2 mean POP (%)

70.6 (69.5 to 71.7)

69.3 (66.4 to 71.3)

P =0.09

SvO2 mean POP ^* (%)

68.4 (67.1 to 69.5)

68.5 (66.5 to 70.4)

P =0.86

PAP mean POP ^* (mmHg)

28.3 (27.6 to 29.2)

30.4 (29.0 to 32.2)

P =0.03

RPP mean POP (mmHg)

60.5 (59.9 to 61.4)

57.4 (56.0 to 59.0)

P <0.001

CI mean POP ^* (l/min/m2)

3.2 (3.0 to 3.3)

3.0 (2.8 to 3.1)

P =0.006

Dobutamine - IOP (no. of pts. (%))

P =0.03

0

195 (46.5)

60 (36.4)

<15 mg/h

93 (22.2)

37 (22.4)

15 - 30 mg/h

115 (27.4)

54 (32.7)

>30 mg/h

16 (3.8)

14 (8.5)

Dobutamine - POP (no. of pts. (%))

P <0.001

0

159 (37.9)

40 (24.2)

<15 mg/h

137 (32.7)

47 (28.5)

15 - 30 mg/h

107 (25.5)

57 (34.5)

>30 mg/h

16 (3.8)

21 (12.7)

PDE - III - IOP (no. of pts. (%))

P =0.001

0

258 (61.6)

77 (46.7)

Low dose

28 (6.7)

7 (4.2)

Moderate dose

124 (29.6)

74 (44.8)

High dose

10 (2.4)

7 (4.2)

PDE III-I - POP (no. of pts. (%))

P <0.001

0

216 (51.6)

55 (33.3)

Low dose

41 (9.8)

19 (11.5)

Moderate dose

145 (34.6)

79 (47.9)

High dose

16 (3.8)

12 (7.3)

Noradrenaline - IOP (no. of pts. (%))

P =0.054

0

51 (12.2)

11 (6.7)

<0.3 mg/h

192 (45.8)

69 (41.8)

0.3 - 0.6 mg/h

130 (31)

57 (34.5)

<0.6 mg/h

46 (10.9)

28 (16.9)

Noradrenaline - POP (no. of pts. (%))

P <0.001

0

72 (17.2)

18 (10.9)

<0.3 mg/h

205 (48.9)

57 (34.5)

0.3 - 0.6 mg/h

94 (22.4)

47 (28.5)

<0.6 mg/h

48 (11.5)

43 (26.1)

Vasopressine - IOP (no. of pts. (%))

P =0.016

0

393 (93.8)

142 (86.1)

<3 U/h

17 (4.1)

16 (9.7)

3 - 6 Uh

8 (1.9)

7 (4.2)

>6 U/h

1 (0.2)

0 (0)

Vasopressine - POP (no. of pts. (%))

P <0.001

0

384 (91.6)

137 (83)

<3 U/h

31 (7.4)

17 (10.3)

3 - 6 Uh

3 (0.7)

7 (4.2)

> 6 U/h

1 (0.2)

4 (2.4)

Time to first extubation (h)

7 (6 to 7)

8 (7 to 9)

P <0.001

Reintubation

P <0.001

No

409 (97.6)

133 (80.6)

Yes

9 (2.1)

32 (19.4)

Total ventilation time (h)

7 (6 to 7)

9 (7.4 to 11)

P <0.001

Duration of ICU treatment (h)

23 (22 to 23)

66 (38 to 81)

P <0.001

Duration of HDU treatment (h)

70 (65 to 77)

124 (108 to 144)

P <0.001

Mortality 30 d (no. of pts. (%))

1 (0.2)

10 (6.1)

P <0.001