Figure 4
From: Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation
Cytokine production after histone stimulation. (A) IL-8 levels in supernatant from mono mac 6 (MM6) significantly increased after 10 ng/ml (P < 0.05) and 50 μg/ml stimulation for 6 and 24 hours. ***Student's t-test, P <0.001. (B) IL-1ß levels in supernatant from MM6 significantly increased after 50 μg/ml stimulation for 24 hours. **Student's t-test, P <0.05. (C) IL-6 levels in supernatant from MM6 significantly increased after 50 μg/ml stimulation for 6 and 24 hours. ***Student's t-test, P <0.001. (D) TNF-α levels in supernatant from MM6 increased after 6 hours with 10 ng/ml and 50 μg/ml histone stimulation and 50 μg/ml stimulation after 24 hours. *Student's t-test, P <0.05.