Figure 1
From: Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation
Plasma histone H4 concentration in two independent cohorts of septic patients (Cohorts I and II) and associations with disease progression and mortality. (A) Plasma histone concentration in sepsis cohort I (n = 15) and sepsis cohort II (n = 19) on day 1, day 3, day 5, ICU controls (n = 12), patients with multiple organ failure (MOF) (n = 12), minor trauma (n = 7) and multiple trauma (n = 12) patients. All controls were without signs of infection. *Mann-Whitney test (P <0.05) to compare independent groups. (B) Plasma histone H4 at day 1 associated with platelet count at day 5, requirement for renal replacement at day 5, and outcome at day 90. *Mann-Whitney test, P <0.05. RRT+ indicates the requirement of renal replacement therapy; RRT- indicates no requirement for renal replacement therapy.