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Table 2 Patient characteristics at CRRT initiation and outcomes

From: The lower limit of intensity to control uremia during continuous renal replacement therapy

 

Average intensity, mL/kg/h

 
 

<10

10 to 15

15 to 20

>20

P -value

Vasopressor use

54 (84.4%)

92 (66.7%)

45 (66.2%)

32 (69.6%)

0.06

Mean arterial pressure, mmHg

73 (65, 84)

71 (60, 80)

73 (64, 83)

67 (57, 80)

0.23

Mechanical ventilation

53 (82.8%)

111 (80.4%)

58 (85.3%)

41 (89.1%)

0.55

PaO2/FiO2 ratio, Torr

215 (152, 300)

197 (136, 300)

226 (134, 331)

208 (125, 336)

0.83

Lactate, mmol/L

2.4 (1.5, 5.7)

2.5 (1.4, 5.2)

2.4 (1.4, 4.3)

3.4 (1.5, 8.0)

0.61

Glasgow coma scale

14 (11, 15)

14 (10, 15)

14 (9, 15)

12 (6, 15)

0.05

Platelet count, 103/μL

107 (59, 163)

90 (52, 142)

84 (51, 156)

88 (56, 154)

0.55

Bilirubin, mmol/L

20.5 (12.0, 54.7)

18.8 (10.3, 37.6)

15.4 (8.6, 40.6)

17.7 (8.6, 42.3)

0.26

Diuretics use

36 (56.3%)

62 (44.9%)

29 (42.7%)

15 (28.3%)

0.035

Urine output, mL/h

17 (5, 45)

21 (9, 40)

22 (9, 53)

16 (5, 42)

0.67

Creatinine, μmol/L

248 (159, 378)

242 (182, 328)

225 (163, 310)

254 (169, 363)

0.55

Urea, mmol/L

18.0 (11.7, 27)

17.7 (12.1, 25.8)

17.5 (10.7, 23.0)

20.0 (14.3, 35.3)

0.14

ICU to start, day

0.9 (0.2, 1.7)

0.9 (0.2, 2.0)

1.0 (0.2, 2.2)

0.4 (0.1, 1.7)

0.44

Mode of CRRT

     

CVVH

6 (9.4%)

7 (5.1%)

1 (1.5%)

4 (8.7%)

0.19

CVVHD

24 (37.5%)

33 (23.9%)

9 (13.2%)

8 (17.4%)

0.008

CVVHDF

34 (53.1%)

98 (71.0%)

58 (85.3%)

34 (73.9%)

0.0008

Blood flow, mL/min

100 (80, 100)

100 (80, 100)

100 (80, 100)

100 (80, 100)

0.89

CRRT dose, L/h

0.60 (0.60, 0.80)

0.80 (0.60, 0.8)

1.0 (0.8, 1.0)

1.3 (1.0, 3.0)

<0.0001

Average intensity, mL/kg/h

8.7 (7.1, 9.2)

12.6 (11.1, 13.9)

16.6 (15.7, 18.3)

24.4 (20.9, 30.9)

<0.0001

CRRT down time (%)

5.8 (0, 21.3)

1.5 (0, 6.2)

2.6 (0.4, 5.2)

1.5 (0, 4.0)

0.014

CRRT duration, days

3.9 (1.9, 6.9)

3.3 (1.7, 6.1)

2.7 (1.7, 5.6)

2.6 (1.3, 4.8)

0.36

ICU mortality

30 (46.9%)

57 (41.3%)

24 (35.3%)

22 (47.8%)

0.47

Hospital mortality

35 (54.7%)

76 (55.1%)

35 (51.5%)

30 (65.2%)

0.53

RRT at discharge among survivors

7 (24.1%)

6 (9.7%)

3 (9.1%)

0 (0%)

0.09

  1. Results are presented as number (%) or median (IQR), ICU to start, duration between ICU admission to continuous renal replacement therapy (CRRT) initiation; CVVH, continuous veno-venous hemofiltration; CVVHD: continuous veno-venous hemodialysis; CVVHDF, continuous veno-venous hemodiafiltration; RRT, renal replacement therapy.