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Table 3 Secondary outcomes

From: Intravenous angiotensin II for the treatment of high-output shock (ATHOS trial): a pilot study

  Hour −2 Hour −1 Hour 0 Hour 1 Hour 2 Hour 3 Hour 4 Hour 5 Hour 6 Hour 7 Hour 8
Urine output, cc           
ATII 41.7 (51.7) 28.6 (32.4) 45.9 (96.5) 31.1 (58.0) 33.7 (67.1) 42.6 (59.8) 35.9 (50.0) 34.4 (57.2) 36.1 (38.3) 27.2 (33.3) 23.8 (27.3)
Placebo 29.5 (69.8) 12.4 (23.2) 23.5 (41.8) 17.5 (25.7) 17.0 (32.0) 16.3 (24.6) 17.0 (34.7) 16.8 (30.4) 14.8 (26.3) 18.0 (27.3) 23.0 (34.4)
Cardiac output, L/min           
ATII 7.0 (2.7) 6.0 (3.1) 6.6 (2.6) 6.3 (2.5) 6.2 (2.5) 5.9 (2.7) 6.5 (2.4) 6.1 (2.6) 6.7 (3.3) 6.3 (2.9) 7.5 (3.1)
Placebo 6.3 (1.2) 6.9 (2.5) 6.5 (1.7) 6.9 (1.8) 6.4 (1.7) 6.8 (3.0) 7.3 (2.2) 6.8 (1.5) 7.3 (1.8) 6.9 (2.5) 7.0 (2.3)
Central venous pressure           
ATII 12.7 (5.5) 12.9 (7.0) 14.1 (8.9) 14.8 (7.3) 14.6 (7.4) 14.8 (8.8) 11.7 (3.9) 12.1 (4.8) 10.0 (2.9) 12.6 (4.8) 11.8 (3.8)
Placebo 16.0 (3.0) 9.7 (2.1) 12.6 (7.8) 15.7 (9.3) 17.3 (9.0) 15.7 (7.3) 16.4 (8.6) 16.3 (6.7) 14.2 (6.5) 14.4 (7.1) 13.2 (5.6)
Mean arterial pressure           
ATII 71.2 (13.6) 72.3 (11.2) 68.8 (7.0) 74.8 (8.4) 69.8 (8.6) 73.1 (12.5) 75.3 (14.2) 68.9 (8.1) 73.0 (10.5) 72.3 (11.9) 73.6 (11.5)
Placebo 71.2 (9.2) 71.8 (6.5) 73.0 (12.6) 72.8 (9.5) 67.8 (6.6) 70.1 (6.4) 71.3 (7.8) 73.0 (4.7) 75.9 (9.4) 74.0 (10.6) 74.5 (13.2)
Lactate           
ATII NA NA 4.6 (3.1) NA NA NA NA NA 5.2 (4.1) NA NA
Placebo NA NA 7.1 (5.2) NA NA NA NA NA 5.7 (3.9) NA NA
  1. All variables are presented as mean (SD). ATII, angiotensin II; NA, to represent not analysed, not applicable, or not available.