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Table 4 Therapeutic intervention and secondary outcomes: Phase II

From: Early versus delayed administration of norepinephrine in patients with septic shock

Characteristic <2 hours (number = 86) ≥2 hours (number = 127) Pvalue
24-hour norepinephrine administration (mg) 29.4 ± 9.7 32.8 ± 10.0 0.013
Time to initial antimicrobial treatment (h) 1.6 ± 1.4 1.7 ± 1.5 0.126
Volume of intravenous fluids within 6 h (L) 3.1 ± 0.9 3.3 ± 0.8 0.092
Volume of intravenous fluids within 24 h (L) 6.2 ± 0.6 6.9 ± 0.7 <0.001
Effective antimicrobial therapy, number (%) 55 (64.0) 87 (68.5) 0.489
Corticosteroid treatment, number (%) 54 (62.8) 74 (58.3) 0.508
Norepinephrine duration (days) 2.6 ± 0.6 2.9 ± 1.0 0.001
Hypotension duration (h) 4.6 ± 1.2 6.1 ± 1.0 <0.001
ICU duration (days) 10.7 ± 6.0 11.2 ± 5.2 0.520