Table 4 Therapeutic intervention and secondary outcomes: Phase II
From: Early versus delayed administration of norepinephrine in patients with septic shock
Characteristic | <2 hours (number = 86) | ≥2 hours (number = 127) | Pvalue |
|---|---|---|---|
24-hour norepinephrine administration (mg) | 29.4 ± 9.7 | 32.8 ± 10.0 | 0.013 |
Time to initial antimicrobial treatment (h) | 1.6 ± 1.4 | 1.7 ± 1.5 | 0.126 |
Volume of intravenous fluids within 6 h (L) | 3.1 ± 0.9 | 3.3 ± 0.8 | 0.092 |
Volume of intravenous fluids within 24 h (L) | 6.2 ± 0.6 | 6.9 ± 0.7 | <0.001 |
Effective antimicrobial therapy, number (%) | 55 (64.0) | 87 (68.5) | 0.489 |
Corticosteroid treatment, number (%) | 54 (62.8) | 74 (58.3) | 0.508 |
Norepinephrine duration (days) | 2.6 ± 0.6 | 2.9 ± 1.0 | 0.001 |
Hypotension duration (h) | 4.6 ± 1.2 | 6.1 ± 1.0 | <0.001 |
ICU duration (days) | 10.7 ± 6.0 | 11.2 ± 5.2 | 0.520 |