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Table 2 Therapeutic intervention and secondary outcomes: Phase I

From: Early versus delayed administration of norepinephrine in patients with septic shock

Characteristic 28-day survivors (n = 133) 28-day non-survivors (n = 80) Pvalue
24-hour norepinephrine administration (mg) 29.4 ± 9.7 34.8 ± 9.6 <0.001
Time to initial norepinephrine administration (h) 2.7 ± 2.1 3.8 ± 2.9 0.002
Time to initial antimicrobial treatment (h) 1.4 ± 1.2 2.2 ± 1.8 0.001
Volume of intravenous fluids within 6 h (L) 3.4 ± 0.9 3.0 ± 0.9 0.003
Volume of intravenous fluids within 24 h (L) 6.5 ± 0.8 6.9 ± 0.5 <0.001
Effective antimicrobial therapy, number (%) 97 (72.9) 45 (56.3) 0.012
Corticosteroid treatment, number (%) 78 (58.6) 50 (62.5) 0.578
Norepinephrine duration (days) 2.4 ± 0.6 3.4 ± 0.9 <0.001
ICU duration (days) 11.2 ± 5.7 10.8 ± 5.4 0.646