Study ID | Number of patients (SBIC/control) | Population | Surgery type | Intervention of SBIC | Definition of CSA-AKI |
---|---|---|---|---|---|
Haase and colleagues [3] | 50/50 | >18 years/at risk of postoperative acute renal dysfunction | Elective or urgent cardiac surgery; CPB | SBIC: 0.5 mmol/kg BW (bolus) 1 hour after the induction of anesthesia; continuous infusion of 0.15 mmol/kg/hour over 23 hours, IV | sCr criteriaa within the first 5 days after CPB |
Del Duca and colleagues [2] | 55/55 | >18 years/ stable CKD | Nonemergency cardiac surgery; CPB | SBIC: 150 mEq, at 1 ml/hour for 6 hours prior to CPB, IV | sCr criteria within the first 5 days after CPB |
Haase and colleagues [4] | 174/176 | >18 years/pre-existing renal impairment | Elective or urgent cardiac surgery; CPB | SBIC: 0.5 mmol/kg BW (bolus) 1 hour after the induction of anesthesia; continuous infusion of 0.2 mmol/kg/hour over 23 hours, IV | Acute Kidney Injury Network criteriab within 5 days after surgery |
Kristeller and colleagues [5] | 44/48 | >18 years/ stage 3 or higher CKD or GFR <60 ml/minute/1.73 m2 | Elective or urgent cardiac surgery; CPB | SBIC: 150 mEq, at 3 ml/kg/hour from 1 hour preoperatively to the patients starting on CPB, IV; continuous infusion of 1 ml/kg/hour during and for 6 hours after CPB, IV | sCr criteria within the first 5 postoperative days |
McGuinness and colleagues [6] | 215/212 | >18 years/ at risk of AKI or pre-existing renal impairment | Elective cardiac surgery; CPB | SBIC: 0.5 mmol/kg BW (=bolus) over 1 hour after the induction of anesthesia; continuous infusion of 0.2 mmol/kg/hour over 23 hours, IV | sCr criteria within the first 5 postoperative days |