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Table 3 Details of subgroup analysis of pooled risk ratio (95%CI) for in-hospital mortality

From: Association of red blood cell transfusion and in-hospital mortality in patients admitted to the intensive care unit: a systematic review and meta-analysis

 

Number of studies included

Effect size (95%CI)

Homogeneity index, Q

Between-study variability, I 2

Type of patient

  

All ICU

7[2],[3],[19],[32],[35],[38],[42]

1.513 (1.123 to 2.039)

39.822, P <0.01

84.933

Sepsis and shock

2[4],[39]

0.831 (0.203 to 3.413)

8.041, P = 0.005

87.563

Surgical

3[21],[34],[37]

1.174 (0.682 to 2.023)

6.793, P = 0.033

70.556

Trauma

3[31],[36],[43]

2.705 (0.815 to 8.973)

30.695, P <0.01

93.484

Other

3[33],[40],[41]

0.940 (0.417 to 2.116)

15.505, P <0.01

87.101

Outcome measurement

  

Count data

2 [19],[31]

3.969 (2.023 to 7.788)

28.936, P <0.01

96.544

OR

10 [2],[3],[32]-[34],[36],[39]-[42]

1.465 (1.049 to 2.045)

30.191, P <0.01

70.190

RR and HR

6 [4],[21],[35],[37],[38],[43]

0.901 (0.622 to 1.305)

31.039, P <0.01

91.391

Adjustment

   

Unadjusted

2 [19],[31]

3.933 (2.107 to 7.343)

28.936, P <0.01

96.544

No propensity matched but multiple adjusted

9 [2],[32]-[34],[39]-[41],[43]

1.358 (0.965 to 1.910)

25.626, P <0.01

68.782

Propensity score matched

7 [3],[4],[21],[35],[37],[38],[42]

1.089 (0.767 to 1.546)

60.523, P <0.01

90.086

Leukoreduced usage

   

Not reported

11 [31]-[34],[36],[37],[39]-[43]

1.851 (1.229 to 2.786)

86.863, P <0.01

88.488

<50%

3[2],[4],[19]

1.155 (0.583 to 2.290)

52.156, P <0.01

96.165

~76%

2 [3],[35]

0.966 (0.412 to 2.267)

14.812, P <0.01

93.249

~100%

2 [21],[38]

1.031 (0.452 to 2.352)

1.261, P = 0.26

20.696

  1. CI, confidence interval; HR, hazard ratio; ICU, intensive care unit; RR, relative risk.