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Figure 2 | Critical Care

Figure 2

From: Endothelial dysfunction is a potential contributor to multiple organ failure and mortality in aged mice subjected to septic shock: preclinical studies in a murine model of cecal ligation and puncture

Figure 2

Determination of lipid peroxidation and myeloperoxidase activity in aorta, mesenteric bed and liver harvested from CLP-injured mice. Tissue malondialdehyde (MDA) levels (index of cellular injury/oxidative stress) and myeloperoxidase (MPO) activity (used as a marker of tissue inflammation) were detected in aorta (Panel A and D), mesenteric vascular bed (Panel B and E) and liver (Panel C and F) harvested from young, aged and eNOS-/- mice subjected to 12 hours of CLP-induced sepsis (*P <0.05 vs. young; n = 5 tissue samples were analyzed in each group of mice). CLP, cecal ligation and puncture; eNOS, endothelial isoform of nitric oxide synthase.

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Critical Care

ISSN: 1364-8535