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Figure 1 | Critical Care

Figure 1

From: Endothelial dysfunction is a potential contributor to multiple organ failure and mortality in aged mice subjected to septic shock: preclinical studies in a murine model of cecal ligation and puncture

Figure 1

Time course of survival rates in young, aged and eNOS-/-mice subjected to CLP. Mice were subjected to acute sepsis by CLP as described in Methods and constantly monitored for 48 hours. Death events were annotated and the Kaplan-Meier estimate was used to compute the survival rates over time. Please notice that by 24 hours the eNOS-deficient mice showed the highest mortality rate (about 70%). At this time there was 40% mortality in the aged mice while no mortality in the wild-type control group (young mice). By 24 to 36 hours all the eNOS-/- mice died, the mortality of the aged mice increased to about 60% while all the young mice survived. By 48 hours, the survival rates of the aged mice and the young mice were 20% and 50% respectively. Sham-operated mice showed no mortality in the 48-hour time frame (not shown) (P = 0.008 eNOS-/- vs. young and P = 0.024 aged vs. young; n = 12/group). CLP, cecal ligation and puncture; eNOS, endothelial isoform of nitric oxide synthase.

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Critical Care

ISSN: 1364-8535