Dynamic gene expressions of peripheral blood mononuclear cells in patients with acute exacerbation of chronic obstructive pulmonary disease: a preliminary study

Wu, Xiaodan; Sun, Xiaoru; Chen, Chengshui; Bai, Chunxue; Wang, Xiangdong

doi:10.1186/s13054-014-0508-y

Critical Care

Table 6 Genes upregulated between 15- and 20-fold in peripheral blood mononuclear cells of patients with stable COPD or AECOPD compared with healthy control subjects ^a

From: Dynamic gene expressions of peripheral blood mononuclear cells in patients with acute exacerbation of chronic obstructive pulmonary disease: a preliminary study

Stable vs control		AE-1 vs control		AE-3 vs control		AE-10 vs control
Fold changes	Genes	Fold changes	Genes	Fold changes	Genes	Fold changes	Genes
15.2	LOC645558	15.0	CNN3	15.0	GPR109B	15.0	USP54
15.7	N/A	15.0	GPT2	15.0	LOC653492	15.0	MGC45438
15.9	LOC653455	15.1	ORM1	15.2	RNASE1	15.2	SLCO2A1
15.9	DUX4	15.1	LOC402110	15.3	FN1	15.3	AGER
16.1	LOC653768	15.1	MDK	15.5	ACSL1	15.3	FLJ11259
16.5	RAB17	15.2	ELF3	15.5	CDH5	15.5	CLEC3B
16.6	LOC653541	15.2	PSG8	15.6	FOLR3	15.8	ADCY4
16.6	LOC391763	15.3	SLC25A37	15.8	PVRL2	16.0	FN1
16.7	LOC642286	15.4	FKBP9	15.9	KRT19	16.1	HP
16.7	S100A14	15.5	C1QB	15.9	MDK	16.1	CKB
16.7	NBPF9	15.6	BPGM	16.0	APOC1	16.1	CYP4B1
16.9	PSG8	15.7	AQP9	16.3	NOL3	16.2	RARRES2
17.0	REXO1L6P	15.7	LOC402207	16.3	ATP1B1	16.3	TSPAN1
17.0	MLPH	15.7	PSG11	16.4	TMC4	16.6	SDC4
17.1	FAM90A7	16.0	KLK11	16.4	VEGF	16.7	ERG
17.4	LOC401650	16.2	KIAA0703	16.6	SPAG4	16.8	LOC653107
17.8	DUB3	16.2	IGFBP5	16.8	LIF	17.2	RAB25
17.9	MGC45438	16.2	IGFBP3	16.8	CCDC80	17.2	COL1A2
18.9	COL3A1	16.2	N/A	16.9	CEACAM3	17.3	DCN
19.1	LOC645732	16.2	SLC25A37	16.9	IGFBP3	17.5	TSPAN13
19.8	LOC392188	16.3	SIX1	17.1	CXCL2	17.6	HSD17B6
20.0	MUC1	16.3	LOC645009	17.2	FKBP9	17.8	RHOB
		16.4	C1QA	17.2	CEACAM1	17.9	KRT19
		16.5	UBD	17.7	ELF3	18.0	AQP9
		16.6	LOC653342	17.7	CNN3	18.2	FOLR1
		17.0	GPR97	17.8	PGLYRP1	18.2	IL1RL1
		17.1	COL1A1	17.9	KRT23	18.2	SERPING1
		17.3	ALPL	18.1	SLC44A4	18.3	MGC35295
		17.4	FBLN1	18.1	SCNN1A	18.4	FLJ43663
		17.5	HIG2	18.4	FBLN1	18.6	TGM2
		17.7	COL8A1	18.5	HPR	18.6	ADH1C
		17.9	TMC5	18.6	SYT7	18.7	KIAA1026
		18.1	LTBP2	18.6	CEACAM8	19.1	DKFZP686A01247
		18.4	SLC25A37	18.8	C1R	19.2	CCDC48
		18.7	CEACAM3	18.8	COL1A1	19.2	ANKRD25
		18.9	MPO	18.9	COL8A1	19.3	DMBT1
		19.0	CD24	18.9	C1QC	19.4	MALL
		19.0	CHI3L1	18.9	SFRP2	19.5	ANXA8
		19.0	DCN	19.0	HIG2	19.5	SPRY4
		19.1	P8	19.2	C1QB	19.7	ELF3
		19.1	CEACAM6	19.2	GPRC5A	19.9	EHD2
		19.1	ACSL1	19.3	MMP25	20.0	DCN
		19.5	PRTN3	19.3	UBD
		19.5	LIF	19.3	GADD45A
		19.6	LTF	19.4	ISLR
		19.7	ANXA3	19.5	ORM1
		19.7	C1R	19.5	C20orf114
		19.7	MUC1	19.5	LOC203510
		19.8	PSG4	19.6	DCN
		19.9	HP	19.7	FN1
				19.8	DAAM2
				19.9	FOLR3

^aData are from patients with stable chronic obstructive pulmonary disease (Stable) or acute exacerbation of chronic obstructive pulmonary disease on day 1 (AE-1), day 3 (AE-3) and day 10 (AE-10) of hospital admission, as compared to healthy controls.

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