Table 18 Number of co–differentially up- or downregulated genes in peripheral blood mononuclear cells of patients with AECOPD compared to patients with stable COPD and healthy control subjects a
Fold change | >5 | >10 | |||||
|---|---|---|---|---|---|---|---|
Upregulated | 58 | 8 | |||||
Fold change | >2 | >3 | |||||
Downregulated | 238 | 8 | |||||
Selected co–differentially upregulated genes (>10-fold) | |||||||
SEQ_ID | Gene name | AE-1 | AE-3 | AE-10 | |||
AE-1 vs Con | AE-1 vs Stable | AE-3 vs Con | AE-3 vs Stable | AE-10 vs Con | AE-10 vs Stable | ||
BC004490 | FOS | 27.4 | 28.6 | 33.5 | 34.9 | 13.2 | 13.7 |
BC015492 | IFI27 | 12.3 | 10.3 | 13.1 | 11.0 | 21.6 | 18.1 |
NM_001554 | CYR61 | 12.0 | 40.3 | 11.2 | 37.6 | 11.7 | 39.2 |
NM_001901 | CTGF | 35.7 | 26.6 | 36.9 | 27.5 | 59.3 | 44.2 |
NM_003979 | GPRC5A | 21.2 | 12.6 | 19.2 | 11.4 | 75.8 | 45.1 |
NM_006732 | FOSB | 21.7 | 13.7 | 40.1 | 25.3 | 35.6 | 22.5 |
NM_133504 | DCN | 19.0 | 17.2 | 19.6 | 17.8 | 20.0 | 18.1 |
XM_373497 | LOC387763 | 41.4 | 13.5 | 46.4 | 15.2 | 41.3 | 13.5 |
Selected co–differentially downregulated genes (>3-fold) | |||||||
SEQ_ID | Gene names | AE-1 | AE-3 | AE-10 | |||
AE-1 vs Con | AE-1 vs Stable | AE-3 vs Con | AE-3 vs Stable | AE-10 vs Con | AE-10 vs Stable | ||
AJ002102 | KIR2DS2 | 3.7 | 3.8 | 7.4 | 7.6 | 4.2 | 4.4 |
BC022407 | SH2D1B | 3.0 | 3.7 | 4.8 | 5.9 | 3.1 | 3.8 |
BC066595 | SH2D1B | 3.6 | 3.2 | 9.9 | 8.9 | 3.6 | 3.2 |
BC100911 | CD8B | 11.2 | 4.4 | 16.0 | 6.3 | 7.9 | 3.1 |
NM_001004698 | OR2W5 | 3.7 | 3.1 | 4.7 | 4.0 | 3.7 | 3.1 |
NM_004931 | CD8B | 10.3 | 5.3 | 11.5 | 5.9 | 6.6 | 3.4 |
NM_031950 | KSP37 | 4.8 | 5.0 | 9.8 | 10.2 | 3.0 | 3.1 |
NM_201633 | TCF7 | 15.6 | 5.6 | 30.4 | 10.8 | 8.9 | 3.2 |