Table 17 Number and details of co–differentially up- or downregulated genes in peripheral blood mononuclear cells of patients with stable COPD or AECOPD compared to healthy control subjects a
Fold change | >5 | >10 | ||||
|---|---|---|---|---|---|---|
Upregulated | 79 | 14 | ||||
Downregulated | 23 | 2 | ||||
Unexpressed genes (>10) | ||||||
SEQ-ID | Gene name | Full name of gene | Stable vs Con | AE-1 vs Con | AE-3 vs Con | AE-10 vs Con |
D12502 | CEACAM1 | Carcinoembryonic antigen-related cell adhesion molecule 1 | 10.1 | 83.0 | 66.5 | 10.5 |
NM_004369 | COL6A3 | Collagen, type VI, α3 | 10.4 | 21.0 | 22.4 | 10.8 |
AF064599 | NOL3 | Nucleolar protein 3 (apoptosis repressor with CARD domain) | 12.1 | 13.6 | 16.3 | 11.5 |
BC042586 | COL1A2 | Collagen, type I, α2 | 13.1 | 72.3 | 92.9 | 17.2 |
BC014473 | CEACAM1 | Carcinoembryonic antigen-related cell adhesion molecule 1 | 14.7 | 101.2 | 61.0 | 11.8 |
AY358857 | MLPH | Melanophilin | 17.0 | 10.3 | 12.8 | 12.2 |
AF348143 | MUC1 | Mucin 1, cell surface-associated | 20.0 | 19.7 | 20.1 | 28.6 |
NM_012385 | P8 | p8 protein (candidate of metastasis 1) | 20.1 | 19.1 | 21.3 | 22.1 |
BC093946 | UNQ473 | DMC | 20.2 | 45.9 | 53.1 | 24.3 |
NM_001305 | CLDN4 | Claudin 4 | 23.0 | 34.4 | 39.1 | 20.7 |
NM_002933 | RNASE1 | Ribonuclease, RNase A family, 1 (pancreatic) | 26.9 | 12.5 | 15.2 | 37.2 |
BC053636 | H19 | H19, imprinted maternally expressed untranslated mRNA | 29.5 | 37.2 | 28.0 | 11.8 |
BC069423 | DEFA1 | Defensin, α1 | 33.0 | 96.1 | 86.7 | 10.2 |
XM_928349 | LOC653600 | Similar to neutrophil defensin 1 precursor (HNP-1) (HP-1) (HP1) (defensin, α1) | 43.1 | 115.8 | 109.4 | 12.8 |
Downregulated genes (>5) | ||||||
SEQ-ID | Gene name | Full name of genes | Stable vs Con | AE-1 vs Con | AE-3 vs Con | AE-10 vs Con |
M38056 | HLA-DOA | Major histocompatibility complex, class II, DOα | 5.3 | 5.9 | 5.6 | 7.3 |
AY209188 | SAA3P | Serum amyloid A3 pseudogene | 5.3 | 6.7 | 6.4 | 11.9 |
BC069511 | UBASH3A | Ubiquitin-associated and SH3 domain-containing, A | 5.5 | 10.4 | 14.3 | 6.9 |
AJ421515 | CRTAC1 | Cartilage acidic protein 1 | 5.6 | 25.4 | 12.5 | 11.9 |
AL133666 | EPHA6 | EPH receptor A6 | 5.6 | 5.8 | 8.2 | 5.3 |
NM_020152 | C21orf7 | Chromosome 21 open reading frame 7 | 5.7 | 8.2 | 9.7 | 10.4 |
XM_089384 | TTC24 | Tetratricopeptide repeat domain 24 | 5.8 | 11.7 | 12.5 | 12.7 |
NM_006850 | IL24 | Interleukin 24 | 6.0 | 6.5 | 10.7 | 11.1 |
AL713701 | C21orf7 | Chromosome 21 open reading frame 7 | 6.1 | 9.5 | 9.5 | 10.0 |
XM_931594 | LOC643514 | Hypothetical protein LOC643514 | 6.2 | 11.4 | 5.7 | 7.4 |
NM_006159 | NELL2 | NEL-like 2 (chicken) | 6.3 | 11.5 | 7.3 | 10.0 |
NM_002348 | LY9 | Lymphocyte antigen 9 | 6.7 | 8.2 | 7.4 | 6.5 |
XM_934852 | LOC129293 | Hypothetical protein LOC129293 | 6.9 | 14.5 | 12.9 | 9.4 |
BC062589 | LY9 | Lymphocyte antigen 9 | 6.9 | 7.3 | 7.1 | 5.5 |
XM_934149 | KIAA0748 | KIAA0748 | 7.0 | 7.5 | 11.2 | 6.2 |
BC008567 | C21orf7 | Chromosome 21 open reading frame 7 | 7.3 | 6.3 | 7.5 | 7.7 |
NM_138363 | CCDC45 | Coiled-coil domain containing 45 | 7.8 | 6.4 | 5.9 | 5.2 |
BC022101 | UNQ470 | GAAI470 | 7.8 | 44.1 | 18.1 | 32.3 |
BC027920 | LY9 | Lymphocyte antigen 9 | 7.9 | 6.2 | 5.8 | 5.3 |
BC033896 | AK5 | Adenylate kinase 5 | 8.2 | 8.2 | 10.6 | 9.9 |
XM_085151 | YLPM1 | YLP motif containing 1 | 10.7 | 8.7 | 5.1 | 7.4 |
NM_014553 | TFCP2L1 | Transcription factor CP2-like 1 | 16.1 | 21.8 | 32.0 | 14.9 |
NM_001007098 | SCP2 | Sterol carrier protein 2 | 21.0 | 27.9 | 18.7 | 18.6 |