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Table 13 Genes downregulated between eight- and tenfold in peripheral blood mononuclear cells of patients with stable COPD or AECOPD compared to healthy control subjects a

From: Dynamic gene expressions of peripheral blood mononuclear cells in patients with acute exacerbation of chronic obstructive pulmonary disease: a preliminary study

Stable vs Con

AE-1 vs Con

AE-3 vs Con

AE-10 vs Con

Fold changes

Genes

Fold changes

Genes

Fold changes

Genes

Fold changes

Genes

8.2

AK5

8.1

CD3G

8.0

TRBV19

8.1

HFE2

8.6

TRA@

8.2

LY9

8.0

OTOA

8.2

TRA@

9.1

ZC3HAV1

8.2

AK5

8.1

CD7

8.6

UNQ470

9.3

MAL

8.2

C21orf7

8.1

GRAP2

8.6

CD248

9.7

TMEM50B

8.2

TRBC1

8.1

TNFRSF25

8.6

XG

  

8.3

ANKDD1A

8.2

C21orf7

8.7

ATG9B

  

8.4

CD6

8.2

EPHA6

8.8

LOC339778

  

8.4

RPS6KB1

8.2

GIMAP5

8.9

TCF7

  

8.5

TMEM50B

8.3

1-Sep

8.9

CCR7

  

8.7

YLPM1

8.3

UBASH3A

9.2

LOC644663

  

8.7

TRBV19

8.4

GIMAP7

9.4

LOC129293

  

8.8

FLT3LG

8.5

MGC23244

9.5

MGC39606

  

8.9

N/A

8.6

LOC645852

9.7

GZMK

  

9.1

LEF1

8.7

SCAP1

9.9

AK5

  

9.1

GZMK

9.0

HIST1H3H

9.9

TCF7

  

9.1

KIAA0748

9.0

HFE2

  
  

9.2

ABLIM1

9.2

GFI1B

  
  

9.5

C21orf7

9.2

TMEM50B

  
  

9.5

ATG9B

9.5

N/A

  
  

9.6

LCK

9.5

C21orf7

  
  

9.6

LOC647353

9.6

GATA3

  
  

9.8

CCR7

9.7

C21orf7

  
  

9.8

UNQ470

9.7

CD247

  
  

9.9

OR10A4

9.8

LCK

  
  

9.9

IL12RB1

9.8

KSP37

  
    

9.9

FAIM3

  
    

9.9

SPOCK2

  
    

9.9

TRA@

  
    

9.9

SH2D1B

  
    

10.0

GRAP2

  
  1. aData are from patients with stable chronic obstructive pulmonary disease (Stable) or acute exacerbation of chronic obstructive pulmonary disease on day 1 (AE-1), day 3 (AE-3) and day 10 (AE-10) of the hospital admission, as compared to healthy controls (Con).