Dynamic gene expressions of peripheral blood mononuclear cells in patients with acute exacerbation of chronic obstructive pulmonary disease: a preliminary study

Table 12 Genes downregulated more than tenfold in peripheral blood mononuclear cells of patients with stable COPD or AECOPD compared to healthy control subjects ^a

Stable vs Con		AE-1 vs Con		AE-3 vs Con		AE-10 vs Con
Fold changes	Genes	Fold changes	Genes	Fold changes	Genes	Fold changes	Genes
10.7	EIF3S6	10.3	HAND1	10.2	GZMK	10.0	C21orf7
10.7	YLPM1	10.3	CD8B	10.5	CXCR3	10.0	NELL2
16.1	TFCP2L1	10.4	UBASH3A	10.6	AK5	10.4	C21orf7
21.0	SCP2	10.8	TRA@	10.7	TRA@	10.4	GFI1B
		10.9	TRBV3-1	10.7	IL24	10.5	LOC129293
		11.2	CD8B	10.9	CD6	10.5	LOC123876
		11.4	MAL	10.9	N/A	10.7	HIST1H3H
		11.4	LOC643514	11.2	KIAA0748	11.1	IL24
		11.5	NELL2	11.4	LCK	11.4	GFI1B
		11.7	TTC24	11.5	CD8B	11.9	CRTAC1
		12.7	CD8B	12.3	APBB1	11.9	OR10A4
		13.1	LEF1	12.3	IL12RB1	11.9	SAA3P
		13.8	TCF7	12.5	TTC24	12.7	TTC24
		14.2	LOC129293	12.5	GFI1B	14.9	TFCP2L1
		14.5	LOC129293	12.5	CRTAC1	18.6	SCP2
		15.6	TCF7	12.6	TRBV3-1	32.3	UNQ470
		16.1	TCF7	12.6	ATG9B
		16.8	CD8B	12.9	ABLIM1
		21.8	TFCP2L1	12.9	LOC129293
		25.4	CRTAC1	13.0	CD8B
		27.9	SCP2	13.1	CD28
		44.1	UNQ470	13.1	GRAP2
				14.3	UBASH3A
				14.4	CCR7
				15.0	LOC129293
				16.0	CD8B
				18.1	UNQ470
				18.7	SCP2
				18.8	LEF1
				19.3	LEF1
				23.5	CD8B
				24.3	TCF7
				25.1	TCF7
				30.4	TCF7
				32.0	TFCP2L1

^aData are from patients with stable chronic obstructive pulmonary disease (Stable) or acute exacerbation of chronic obstructive pulmonary disease on day 1 (AE-1), day 3 (AE-3) and day 10 (AE-10) of the hospital admission, as compared to healthy controls (Con).

ISSN: 1364-8535