Dynamic gene expressions of peripheral blood mononuclear cells in patients with acute exacerbation of chronic obstructive pulmonary disease: a preliminary study

Table 1 Clinical phenotypes of healthy controls, patients with stable chronic obstructive pulmonary disease and patients with acute exacerbation of chronic obstructive pulmonary disease ^a

Groups	Subject no.	Age (yr)	Smoking status	FEV ₁/FVC%	FEV ₁/pred%	Goddard emphysema score
Control	1	56	Nonsmoker	75	85	0
	2	53	Nonsmoker	80	87	0
	3	62	Nonsmoker	77	91	0
	4	68	Nonsmoker	81	83	0
	5	58	Nonsmoker	79	81	0
	6	67	Nonsmoker	76	90	0
Mean ± SE		60.7 ± 2.5		78.0 ± 1.0	86.2 ± 1.6	0.0 ± 0.0
Stable COPD	1	71	Ex-smoker	57	47	10
	2	75	Ex-smoker	46	66	6
	3	61	Ex-smoker	46	47	8
	4	57	Ex-smoker	38	29	12
	5	59	Ex-smoker	67	66	7
	6	53	Ex-smoker	29	36	11
Mean ± SE		62.7 ± 3.5		47.2 ± 5.5	48.5 ± 6.2	9.0 ± 1.0
AECOPD	1	77	Ex-smoker	40	42	10
	2	72	Ex-smoker	36	27	11
	3	65	Ex-smoker	28	33	16
	4	56	Ex-smoker	48	61	6
	5	61	Ex-smoker	69	55	4
	6	67	Ex-smoker	56	60	8
Mean ± SE		66.3 ± 3.1		46.2 ± 6.0	46.3 ± 5.9	9.2 ± 1.7

^aAECOPD, Acute exacerbation of chronic obstructive pulmonary disease; COPD, Chronic obstructive pulmonary disease; FEV₁, Forced expiratory volume in 1 second; FVC, Forced vital capacity; pred, Prediction. Data represent information gathered on days 1, 3 and 10 of hospital admission.

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