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Table 6 Cox regression models to predict 30-day and 6-month all-cause mortality at days 1, 3 and 8 of intensive care treatment

From: Diagnostic and prognostic utility of soluble CD 14 subtype (presepsin) for severe sepsis and septic shock during the first week of intensive care treatment

 

Model 1

Model 2

 

Unadjusted

Adjusted for age, sex, creatinine, ICU days, APACHE II

Predictor

HR

95% CI

Chi-square

P-value

HR

95% CI

Chi-square

P-value

All-cause mortality 30 days

    

Day 1

    

Log presepsin, pg/ml

1.9

1.2, 3.0

6.9

0.009

2.2

1.2, 4.1

42.9

0.02

Log interleukin 6, pg/ml

1.7

1.4, 2.2

20.5

0.0001

1.9

1.4, 2.7

54.7

0.0001

Day 3

    

Log presepsin, pg/ml

1.8

1.0, 3.3

3.7

0.05

1.3

0.5, 3.3

4.9

0.7

Log interleukin 6, pg/ml

2.6

1.6, 4.4

13.2

0.0001

3.2

2.0, 5.4

28.3

0.0001

Day 8

    

Log presepsin, pg/ml

2.5

1.3, 5.0

7.4

0.007

7.5

2.4, 23.3

22.6

0.001

Log interleukin 6, pg/ml

3.9

1.6, 9.4

9.2

0.003

6.0

1.9, 19.2

18.3

0.002

All-cause mortality 6 months

    

Day 1

        

Log presepsin, pg/ml

2.0

1.3, 3.0

10.6

0.001

2.7

1.5, 4.9

32.0

0.001

Log interleukin 6, pg/ml

1.7

1.3, 2.1

19.3

0.0001

1.7

1.3, 2.3

36.5

0.0001

Day 3

        

Log presepsin, pg/ml

1.9

1.2, 3.2

6.5

0.01

1.5

0.6, 3.4

3.3

0.4

Log interleukin 6, pg/ml

2.7

1.7, 4.3

16.6

0.0001

3.1

1.9, 4.9

22.3

0.0001

Day 8

        

Log presepsin, pg/ml

2.6

1.5, 4.3

12.7

0.0001

4.5

2.0, 10.4

17.2

0.0001

Log interleukin 6, pg/ml

3.1

1.6, 6.1

11.5

0.001

3.5

1.5, 7.8

12.3

0.003

  1. Hazard ratios (HR) describe the HR for a biomarker change per log unit-increase. APACHE II, acute physiology and chronic health evaluation II score.