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Table 6 Cox regression models to predict 30-day and 6-month all-cause mortality at days 1, 3 and 8 of intensive care treatment

From: Diagnostic and prognostic utility of soluble CD 14 subtype (presepsin) for severe sepsis and septic shock during the first week of intensive care treatment

  Model 1 Model 2
  Unadjusted Adjusted for age, sex, creatinine, ICU days, APACHE II
Predictor HR 95% CI Chi-square P-value HR 95% CI Chi-square P-value
All-cause mortality 30 days     
Day 1     
Log presepsin, pg/ml 1.9 1.2, 3.0 6.9 0.009 2.2 1.2, 4.1 42.9 0.02
Log interleukin 6, pg/ml 1.7 1.4, 2.2 20.5 0.0001 1.9 1.4, 2.7 54.7 0.0001
Day 3     
Log presepsin, pg/ml 1.8 1.0, 3.3 3.7 0.05 1.3 0.5, 3.3 4.9 0.7
Log interleukin 6, pg/ml 2.6 1.6, 4.4 13.2 0.0001 3.2 2.0, 5.4 28.3 0.0001
Day 8     
Log presepsin, pg/ml 2.5 1.3, 5.0 7.4 0.007 7.5 2.4, 23.3 22.6 0.001
Log interleukin 6, pg/ml 3.9 1.6, 9.4 9.2 0.003 6.0 1.9, 19.2 18.3 0.002
All-cause mortality 6 months     
Day 1         
Log presepsin, pg/ml 2.0 1.3, 3.0 10.6 0.001 2.7 1.5, 4.9 32.0 0.001
Log interleukin 6, pg/ml 1.7 1.3, 2.1 19.3 0.0001 1.7 1.3, 2.3 36.5 0.0001
Day 3         
Log presepsin, pg/ml 1.9 1.2, 3.2 6.5 0.01 1.5 0.6, 3.4 3.3 0.4
Log interleukin 6, pg/ml 2.7 1.7, 4.3 16.6 0.0001 3.1 1.9, 4.9 22.3 0.0001
Day 8         
Log presepsin, pg/ml 2.6 1.5, 4.3 12.7 0.0001 4.5 2.0, 10.4 17.2 0.0001
Log interleukin 6, pg/ml 3.1 1.6, 6.1 11.5 0.001 3.5 1.5, 7.8 12.3 0.003
  1. Hazard ratios (HR) describe the HR for a biomarker change per log unit-increase. APACHE II, acute physiology and chronic health evaluation II score.