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Table 5 Prognostic performance of biomarkers and ICU scores for 30-day and 6-month all-cause mortality during the first week of ICU treatment

From: Diagnostic and prognostic utility of soluble CD 14 subtype (presepsin) for severe sepsis and septic shock during the first week of intensive care treatment

  Presepsin Interleukin-6 Procalcitonin C-reactive protein Leukocytes SOFA APACHE II
AUC (95% CI)
30-day all-cause mortality   
Day 1 0.64 0.69 0.59 0.54 0.51 0.64 0.70
(0.54, 0.75) (0.55, 0.76) (0.48, 0.69) (0.43, 0.65) (0.41, 0.62) (0.52, 0.77) (0.60, 0.80)
P = 0.008 P = 0.001 P = 0.1 P = 0.5 P = 0.8 P = 0.05 P = 0.0001
Day 3 0.70 0.69 0.58 0.64 0.55 0.65 0.64
(0.59, 0.81) (0.58, 0.80) (0.46, 0.70) (0.52, 0.76) (0.42, 0.67) (0.53, 0.77) (0.51, 0.77)
P = 0.002 P = 0.002 P = 0.2 P = 0.03 P = 0.5 P = 0.04 P = 0.04
Day 8 0.69 0.67 0.57 0.61 0.60 0.69 0.60
(0.56, 0.82) (0.54, 0.81) (0.41, 0.73) (0.46, 0.75) (0.46, 0.75) (0.57, 0.81) (0.42, 0.78)
P = 0.02 P = 0.03 P = 0.4 P = 0.2 P = 0.2 P = 0.007 P = 0.3
58 of 116 patients died after 30 days corresponding to a 50% all-cause mortality rate.
6 months all-cause mortality   
Day 1 0.68 0.66 0.59 0.57 0.54 0.67 0.65
(0.58, 0.78) (0.56, 0.76) (0.49, 0.70) (0.45, 0.69) (0.43, 0.65) (0.55, 0.78) (0.54, 0.76)
P = 0.001 P = 0.05 P = 0.1 P = 0.2 P = 0.5 P = 0.01 P = 0.01
Day 3 0.70 0.70 0.57 0.61 0.59 0.64 0.61
(0.59, 0.80) (0.59, 0.80) (0.45, 0.69) (0.49, 0.73) (0.47, 0.71) (0.52, 0.76) (0.48, 0.74)
P = 0.002 P = 0.001 P = 0.3 P = 0.08 P = 0.2 P = 0.04 P = 0.1
Day 8 0.71 0.67 0.56 0.63 0.60 0.71 0.64
(0.58, 0.83) (0.54, 0.80) (0.42, 0.70) (0.49, 0.77) (0.46, 0.74) (0.60, 0.83) (0.44, 0.84)
P = 0.004 P = 0.02 P = 0.4 P = 0.06 P = 0.2 P = 0.001 P = 0.2
72 of 116 patients died after 6 months corresponding to a 62% all-cause mortality rate.
  1. Significant P-values (P <0.05) are highlighted in bold type. AUC, area under the curve; APACHE II, acute physiology and chronic health evaluation II; SOFA, sequential organ failure assessment.