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Table 3 Diagnostic performance of biomarkers for diagnosis of severe sepsis and septic shock at days 1, 3 and 8 of ICU treatment, analyzed as area under the curve (95% CI)

From: Diagnostic and prognostic utility of soluble CD 14 subtype (presepsin) for severe sepsis and septic shock during the first week of intensive care treatment

  Presepsin Interleukin-6 Procalcitonin C-reactive protein White blood cells
Day 1   
Septic shock (n = 74) 0.80 (0.73, 0.86) 0.86 (0.80, 0.91) 0.83 (0.77, 0.90) 0.62 (0.49, 0.74) 0.53 (0.41, 0.62)
P?= 0.0001 P = 0.0001 P = 0.0001 P = 0.06 P = 0.7
Day 1: Controls n = 60; SIRS n = 9; sepsis n = 5; severe sepsis n = 28; septic shock n = 74
Day 3      
≥ Sepsis (n = 81) 0.84 (0.72, 0.96) 0.81 (0.70, 0.92) 0.69 (0.52, 0.87) 0.69 (0.54, 0.83) 0.73 (0.60, 0.87)
P = 0.0001 P = 0.001 P = 0.03 P = 0.04 P = 0.009
≥ Severe sepsis (n = 67) 0.80 (0.70, 0.91) 0.71 (0.60, 0.81) 0.66 (0.52, 0.80) 0.61 (0.49, 0.74) 0.59 (0.47, 0.72)
P = 0.0001 P = 0.003 P = 0.02 P = 0.1 P = 0.2
Septic shock (n = 39) 0.72 (0.61, 0.82) 0.76 (0.66, 0.87) 0.66 (0.55, 0.77) 0.72 (0.62, 0.83) 0.57 (0.45, 0.70)
P = 0.0001 P = 0.0001 P = 0.01 P = 0.0001 P = 0.3
Day 3: SIRS n = 15; sepsis n = 14; severe sepsis n = 28; septic shock n = 39
Day 8   
≥ Sepsis (n = 48) 0.82 (0.71, 0.93) 0.74 (0.61, 0.87) 0.64 (0.50, 0.78) 0.69 (0.54, 0.84) 0.75 (0.64, 0.87)
P = 0.0001 P = 0.001 P = 0.06 P = 0.01 P = 0.001
≥ Severe sepsis (n = 37) 0.77 (0.65, 0.88) 0.73 (0.61, 0.85) 0.68 (0.55, 0.81) 0.65 (0.51, 0.78) 0.71 (0.58, 0.83)
P = 0.0001 P = 0.001 P = 0.01 P = 0.04 P = 0.004
Septic shock (n = 18) 0.79 (0.66, 0.92) 0.69 (0.55, 0.83) 0.78 (0.65, 0.92) 0.67 (0.53, 0.81) 0.68 (0.53, 0.84)
P = 0.0001 P = 0.02 P = 0.001 P = 0.04 P = 0.02
Day 8: SIRS n = 28; sepsis n = 11; severe sepsis n = 19; septic shock n = 18
  1. A minimal area under the curve was set at ≥0.75 (highlighted in bold type). SIRS, systemic inflammatory response syndrome.