Effects of tight computerized glucose control on neurological outcome in severely brain injured patients: a multicenter sub-group analysis of the randomized-controlled open-label CGAO-REA study

Table 2 In-ICU blood glucose events

	Control group	IIT group	P value
	Number = 98	Number = 90	P value
Median of the first five days morning laboratory blood glucose (mmol.l⁻¹)	6.5 (5.6 to 7.2)	5.9 (5.1 to 6.7)	< 0.001^a
Episodes of moderate hypoglycemia	19 (19.3)	46 (51.1)	< 0.001^b
Episodes of severe hypoglycemia	4 (4)	6 (6.6)	0.50
Patients treated with insulin	81 (82.6)	87 (96.6)	0.002^b
Total of insulin dose (IU) in the first five days	74 (13 to 165)	130 (68 to 251	0.01^a

^aStudent’s t test; ^bχ² test. Moderate hypoglycemia was define as a blood glucose level <3.3 mmol.L⁻¹. Severe hypoglycemia was defined as <2.2 mmol.L⁻¹. Continuous data are expressed as median (25^th to 75th percentile) and categorical data as N (%). IIT: intensive insulin therapy.

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