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Table 1 Baseline patient demographics

From: Efficacy and bleeding risk of antithrombin supplementation in septic disseminated intravascular coagulation: a secondary survey

 

AT1500 group n = 259

AT3000 group n = 48

P value

Gender

   

Male

138 (53.3%)

27 (56.3%)

 

Female

121 (46.7%)

21 (43.8%)

 

Age in years

   

14 or under

1 (0.4%)

0 (0.0%)

 

15-64

60 (23.2%)

13 (27.1%)

 

65 or over

198 (76.4%)

35 (32.9%)

 

Suspected source of infection

   

Respiratory tract

85 (32.8%)

11 (22.9%)

 

Digestive tract

78 (30.1%)

25 (52.1%)

<0.05

Urinary tract

19 (7.3%)

2 (4.2%)

 

Biliary tract

28 (10.8%)

4 (8.3%)

 

Others

26 (10.0%)

6 (12.5%)

 

Unknown

35 (13.5%)

2 (4.2%)

 

Surgery

84 (34.0%)

27 (56.3%)

<0.05

Baseline AT activity

   

<30%

88 (34.0%)

19 (39.6%)

 

30%

171 (66.0%)

29 (60.4%)

 

SD

31.02 ± 7.25

29.57 ± 8.22

 

Baseline DIC score

   

4.5

143 (55.2%)

26 (54.2%)

 

6

48 (18.5%)

10 (20.8%)

 

7.8

68 (26.3%)

12 (25.0%)

 

SD

5.6 ± 1.3

5.7 ± 1.4

 

Baseline SOFA score

   

0-6

27 (26.5%)

5 (31.3%)

 

7-12

46 (45.1%)

9 (56.3%)

 

13-24

29 (28.4%)

2 (12.5%)

 

SD

10.1 ± 4.7

7.7 ± 4.3

 

Median baseline platelet count, × 104/mm3

6.0 (IQR 3.15-9.1)

7.9 (IQR 5.0-11.4)

<0.05

Median baseline FDP, μg/mL

22.1 (IQR 11.5-37.8)

23.7 (IQR 5.0-11.4)

<0.05

Heparin

64 (24.7%)

8 (16.7%)

 

Thrombomodulin

15 (5.8%)

3 (6.3%)

 
  1. Values are presented as number (percentage) unless otherwise indicated. AT, antithrombin; DIC, disseminated intravascular coagulation; FDP, fibrin/fibrinogen degradation product; IQR, interquartile range; SD, standard deviation; SOFA, Sepsis-Related Organ Failure Assessment.