In-hospital mortality following treatment with red blood cell transfusion or inotropic therapy during early goal-directed therapy for septic shock: a retrospective propensity-adjusted analysis

Table 4 Multiple regression and propensity score adjusted odds ratio of in-hospital mortality according to treatment with red blood cell (RBC) transfusion or inotropic therapy during early goal-directed therapy (EGDT)

Odds ratio of in-patient mortality	RBC transfusion	P value	Inotrope therapy	P value
Unadjusted (95% CI)	0.93 (0.52-1.66)	0.80	1.33 (0.92-1.92)	0.12
Multivariate regression adjusted (95% CI)	0.58 (0.29-1.18)	0.14	1.10 (0.70-1.73)	0.68
Propensity score (continuous) adjusted (95% CI)	0.42 (0.18-0.97)	0.04	1.16 (0.69-1.96)	0.57
Propensity score (quintile) adjusted (95% CI)	0.46 (0.21-1.04)	0.06	1.21 (0.77-1.91)	0.41

Multivariate logistic regression analysis of the entire cohort was conducted, followed by propensity score adjusted analyses according to the subgroup of hemoglobin nadir during the first six hours of EGDT treatment; patients with a hemoglobin less than 10 g/dL were included in the analysis of RBC transfusion and patients with a hemoglobin of 10 g/dL or greater were included in the inotrope therapy analysis. Standard error and 95% confidence interval (CI) calculations in the regression analyses are adjusted for clustering by hospital.

ISSN: 1364-8535