| Inotropes (n = 186) | No inotropes (n = 207) | Pvalue (unadjusted) | Pvalue (adjusted for propensity score) |
---|---|---|---|---|
Demographics and comorbidities | ||||
Age, years | 76 (67-84) | 72 (61-81) | 0.01 | 0.85 |
Female (%) | 46.8 | 44.9 | 0.74 | 0.58 |
Race | Â | 0.45 | 0.47 | |
White (%) | 58.6 | 62.3 | ||
Asian (%) | 15.1 | 11.6 | ||
Hispanic (%) | 11.8 | 12.6 | ||
African-American (%) | 6.4 | 8.2 | ||
Other (%) | 8.0 | 5.3 | ||
Ischemic heart disease (%) | 31.7 | 30.0 | 0.38 | 0.96 |
Congestive heart failure (%) | 39.8 | 37.2 | 0.60 | 0.91 |
Chronic lung disease (%) | 32.2 | 42.5 | 0.04 | 0.49 |
Diabetes (%) | 34.4 | 34.8 | 0.94 | 0.29 |
HIV/AIDS (%) | 0.5 | 1.0 | 0.63 | 0.66 |
Malignancy (%) | 10.8 | 12.1 | 0.68 | 0.73 |
Rheumatologic disease (%) | 4.8 | 6.3 | 0.54 | 0.57 |
Elixhauser score | 16 (8-21) | 15 (7-23) | 0.64 | 0.38 |
Initial presenting variables | ||||
Systolic blood pressure, mm Hga | 111 (94-130) | 113 (95-132) | 0.57 | 0.23 |
Diastolic blood pressure, mm Hga | 65 (51-80) | 66 (54-78) | 0.51 | 0.31 |
Heart rate, bpma | 108 (92-124) | 108 (90-125) | 0.80 | 0.50 |
Shock indexa | 1.0 (0.8-1.2) | 1.0 (0.8-1.1) | 0.85 | 0.94 |
Shock index ≥ 1.0 | 52.7 | 50.2 | 0.63 | 0.74 |
Serum lactate, mmol/Lb | 4.6 (3.4-6.2) | 4.4 (3.0-6.2) | 0.22 | 0.47 |
Positive initial blood cultures (%) | 34.4 | 31.9 | 0.60 | 0.40 |
EGDT treatment period variables | ||||
Fluid administered by 6 hours, liters | 4.0 (3.0-5.0) | 3.5 (2.5-5.0) | 0.03 | 0.34 |
Peak CVP, mm Hgb | 16 (13-20) | 17 (13-22) | 0.27 | 0.45 |
Hemoglobin nadir, g/dLb | 12.7 (11.6-14.0) | 12.2 (10.9-13.7) | 0.04 | 0.11 |
RBC transfusion (%) | 0 | 0 | n/a | n/a |
Antibiotic therapy within one hour (%) | 95.2 | 90.8 | 0.10 | 0.11 |
Mechanical ventilation (%)b | 30.6 | 34.3 | 0.44 | 0.58 |
Vasopressor administration (%)b | 71.5 | 42.5 | <0.001 | 0.31 |
Initial ScvO2, percentb | 62 (55-70) | 64 (57-69) | 0.44 | 0.07 |
Final ScvO2, percentb | 68 (63-72) | 68 (61-73) | 0.29 | 0.62 |
Final ScvO2 > 70% (%) | 44.4 | 42.3 | 0.68 | 0.80 |
Change in ScvO2, percent | 5 (−2-13) | 3(−4-10) | 0.16 | 0.06 |
Lactate clearance, percent per hourb | 8.2 (4.8-13.0) | 8.5 (4.8-13.6) | 0.40 | 0.38 |
Lactate clearance ≥5% per hour (%) | 74.1 | 74.2 | 0.98 | 0.89 |
mSOFA score at 6 hours | 5 (4-6) | 4 (2-6) | <0.001 | 0.51 |
eSAPS 3 score | 52 (46-58) | 48 (43-55) | 0.02 | 0.71 |
Post-treatment variables | ||||
mSOFA score at 24 hours | 5 (4-7) | 4 (3-6) | 0.001 | 0.21 |
In-hospital mortality (%) | 23.7 | 18.8 | 0.24 | 0.41 |