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Table 2 Propensity score adjustment among patients eligible for RBC transfusion during EGDT

From: In-hospital mortality following treatment with red blood cell transfusion or inotropic therapy during early goal-directed therapy for septic shock: a retrospective propensity-adjusted analysis

  RBCs transfused (n = 71) No RBCs transfused (n = 108) Pvalue (unadjusted) P value (adjusted)
Demographics and comorbidities
Age, years 70 (61-81) 72 (60-84) 0.78 0.84
Female (%) 46.5 50.0 0.65 0.83
Race   0.56 0.45
White (%) 49.3 53.7
Asian (%) 14.1 13.9
Hispanic (%) 14.1 14.8
African-American (%) 14.1 7.4
Other (%) 8.4 10.2
Ischemic heart disease (%) 38.0 28.7 0.19 0.38
Congestive heart failure (%) 32.4 31.4 0.90 0.67
Chronic lung disease (%) 26.7 25.9 0.90 0.87
Diabetes (%) 26.7 40.7 0.06 0.90
HIV/AIDS (%) 1.4 0.9 0.77 0.71
Malignancy (%) 32.4 15.7 0.01 0.93
Rheumatologic disease (%) 9.9 6.5 0.41 0.51
Elixhauser score 19 (11-28) 16 (9-24) 0.05 0.95
Initial presenting variables
Systolic blood pressure, mm Hga 102 (86-113) 107 (92-127) 0.05 0.90
Diastolic blood pressure, mm Hga 56 (44-68) 59 (50-70) 0.51 0.54
Heart rate, bpma 118 (99-130) 109 (90-123) 0.02 0.21
Shock indexa 1.1 (0.9-1.4) 1.0 (0.8-1.2) 0.001 0.27
Shock index ≥1.0 74.6 51.9 0.003 0.11
Serum lactate, mmol/Lb 4.4 (3.6-7.7) 4.3 (2.5-5.7) 0.10 0.74
Positive blood cultures (%) 49.3 34.2 0.05 0.73
EGDT treatment period variables
Fluid administered by 6 hours, liters 4.1 (3.0-5.0) 4.0 (3.0-5.7) 0.37 0.48
Peak CVP, mm Hgb 15 (12-19) 16 (13-22) 0.02 0.57
Hemoglobin nadir, g/dLb 7.9 (7.1-8.8) 9.2 (8.5-9.5) <0.001 0.47
Inotropes (%) 16.9 37.0 0.005 0.36
Antibiotic therapy within one hour (%) 95.8 93.5 0.52 0.40
Mechanical ventilation (%)b 31.0 33.3 0.74 0.74
Vasopressor administration (%)b 62.0 64.8 0.70 0.60
Initial ScvO2, percentb 61 (55-68) 63 (55-69) 0.97 0.87
Final ScvO2, percentb 70 (60-75) 67 (61-71) 0.51 0.36
Final ScvO2 > 70% (%) 51.3 39.1 0.12 0.16
Change in ScvO2, percent 7 (−2-12) 5 (−4-12) 0.54 0.34
Lactate clearance, percent per hourb 9.5 (3.6-13.0) 8.5 (3.9-12.0) 0.13 0.09
Lactate clearance ≥5% per hour (%) 72.4 66.5 0.43 0.28
mSOFA score at 6 hours 5 (3-6) 5 (3-7) 0.41 0.94
eSAPS 3 score 52 (45-59) 50 (44-57) 0.35 0.89
Post-treatment variables
mSOFA score at 24 hours 5 (3-7) 5 (4-7) 0.38 0.85
In-hospital mortality (%) 18.3 19.4 0.85 0.12
  1. A subgroup analysis was conducted among patients with a hemoglobin nadir less than 10 g/dL during EGDT. Unadjusted P values are reported for the observed variables based on whether RBC transfusion was administered for an ScvO2 less than 70%. Adjusted P values are based on bivariate regression analyses comparing the propensity score (for RBC transfusion) and each variable. Continuous values are presented as median values with interquartile ranges in parentheses. Dichotomous variables are presented as percentages.
  2. aAt initial emergency department presentation; bwithin the first six hours from shock recognition (time zero). RBC, red blood cells; EGDT, early goal-directed therapy; HIV/AIDS, human immunodeficiency virus/acquired immunodeficiency syndrome; mm Hg, millimeters mercury; bpm, beats per minute; CVP, central venous pressure; g/dL, grams per deciliter; ScvO2, central venous oxygen saturation; mSOFA, modified sequential organ failure assessment score; eSAPS, electronic simplified acute physiology score.