Figure 3
Mechanical ventilation and applied positive end-expiratory airway pressure effects on mRNA levels. (A) Caspase 3. (B) Insulin-like growth factor 1 (IGF-1). (C) Muscle atrophy F-box (MAFbx). (D) Muscle ring finger protein 1 (MuRF1). Values are mean ± SE (n = 6 animals per group). Caspase 3: *P < 0.01 compared with control. IGF-1: †P < 0.05 for CMV compared with CPAP; and for CMV-8 compared with AMV-8. MAFbx: *P < 0.01 for CMV compared with control, CPAP and AMV; and for CMV-8 compared with control. MuRF1: *P < 0.01 for CMV compared with control, CPAP and AMV; and for CMV-8 compared with control, CPAP-8 and AMV-8. AMV, Assist-control mechanical ventilation; CMV, Controlled mechanical ventilation (numerical value of 8 next to the ventilatory mode denotes the set CPAP or PEEP of 8 cmH2O); CPAP, Continuous positive airway pressure.