Figure 4
From: Renal effects of treatment with a TLR4 inhibitor in conscious septic sheep
Increased renal neutrophil infiltration is attenuated by TLR4 inhibition. Light microscopy with hematoxylin/eosin staining shows an increased number of polymorphonuclear leukocytes (PMNs) (arrows) in the glomeruli and within the interstitium/peritubular capillaries in both vehicle-treated (C) and TAK-242-treated (B) animals in comparison with sham (A). Tubular epithelial injury was seen with pyknotic and disintegrated nuclei in two of the vehicle-treated animals (C) white arrow and (D) arrows—and one of the TAK-242-treated animals.