Figure 2
From: Renal effects of treatment with a TLR4 inhibitor in conscious septic sheep
Changes in diuresis (A), creatinine clearance (Crea Clear) (B), filtration fraction (C), blood urea nitrogen (BUN) (D) plasma creatinine (P-Crea) (E), and urinary concentrations of N-acetyl-ß-D-glucosaminidase (U-NAG) (F) in response to sepsis and treatment with either the selective TLR4 inhibitor TAK-242 (n = 7) or vehicle (n = 7). Data are expressed as mean and 95% confidence interval. Asterisk indicates a significant difference between TAK-242 and control in response to sepsis. Analysis of variance (ANOVA) repeated measures from 12 to 36 hours.