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Table 2 Variables associated with left ventricular dysfunction in subarachnoid hemorrhage patients with Takotsubo cardiomyopathy on univariate analysis a

From: Impact of transpulmonary thermodilution-based cardiac contractility and extravascular lung water measurements on clinical outcome of patients with Takotsubo cardiomyopathy after subarachnoid hemorrhage: a retrospective observational study

Variable LVEF ≥40% (n = 26) LVEF <40% (n = 20) P-value
Daily fluid intake, ml 3,182 ± 564 2,976 ± 569 0.18
 Fluid output, ml 2,939 ± 446 2,782 ± 541 0.21
 Fluid balance, ml 282 ± 163 166 ± 108 0.09
Plasma biochemical markers (peak levels)    
 Cardiac troponin T, ng/ml 1.1 (0.1 to 1.4) 2.0 (0.2 to 4.0) 0.17
 Adrenaline, ng/ml 0.09 (0.03 to 0.14) 0.13 (0.04 to 0.20) 0.10
 Noradrenaline, ng/ml 0.59 (0.26 to 0.76) 0.98 (0.39 to 1.66) 0.11
 Brain natriuretic peptide, pg/ml 80 (21 to 132) 122 (65 to 191) 0.06
Duration of low CFI, days 2 (0 to 3) 6 (4 to 7) 0.0001*
Pulmonary edema after day 4 5 (19%) 11 (55%) 0.013*
Prevalence of DCI 5 (19%) 10 (50%) 0.029*
New or worsened pulmonary edema 2 (8%) 4 (20%) 0.22
Length of ICU stay, days 13 (10 to 14) 15 (14 to 16) 0.02*
mRS score at 3 months    
 0 to 3 18 (69%) 6 (30%) 0.009*
 4 to 6 8 (31%) 14 (70%)  
  1. aCFI: Cardiac function index; DCI: Delayed cerebral ischemia; LVEF: Left ventricular ejection fraction. Numerical variables are presented as median (interquartile range) or mean ± standard deviation. Categorical variables are expressed as counts (percentage). Numerical variables were analyzed by Mann–Whitney U test or unpaired Student t-test. Categorical variables were analyzed by χ2 test or Fisher’s exact test. Pulmonary edema was defined as ELWI >14 ml/kg based on the PiCCO™ measurements. Duration of low CFI was defined by at least one CFI <4.2 min−1 (corresponding to predicted LVEF <40%) over 24 hours. *Significant P-values.