Table 1 Randomized controlled trials of bundled goal-directed therapy
From: Conservative fluid therapy in septic shock: an example of targeted therapeutic minimization
| Study and country | Sign score | Goal-directed therapy (goals) | Time and fluid quantification (L) | ||
|---|---|---|---|---|---|
| Control | GDT | ||||
| Rivers et al. 2001, USA [2] | + | 500 ml crystalloid bolus every 30 minutes (CVP 8–12 mmHg) | 6 h: | 3.5 ± 2.4 | 5.0 ± 3.0 |
| 7–72 h: | 10.6 ± 6.2 | 8.6 ± 5.2 | |||
| Lin et al. 2006, Taiwan [23] | + | 500 ml crystalloid bolus every 30 minutes (CVP 8–12 mmHg) | Total: | 5.0 ± 2.9 | 5.2 ± 4.0 |
| GDT Collaborative Group of Zhejiang Province 2010, China [22] | - | 500 ml crystalloid bolus every 30 minutes (CVP 8–12 mmHg) | Quantified but not reported | ||
| ProCESS 2014, USA [24] | ++ | 500 ml crystalloid bolus every 30 minutes (CVP 8–12 mmHg) | 6 h: | 2.3 ± 1.9 | 2.8 ± 2.0 |