Table 2 Summary of diagnoses related to severe sepsis and opportunistic infections in the intensive care unit from 2005 to 2010
2a: Non-HIV versus all HIV patients | 2b: HIV versus HIV/HCV patients | |||||
|---|---|---|---|---|---|---|
Control group | All-HIV group | P value | HIV group | HIV/HCV group | P value | |
Severe sepsis | 2,954 (39.41%) | 1,092 (57.75%) | <0.001 | 711 (59.70%) | 381 (54.43%) | 0.028 |
Acute organ dysfunction | ||||||
Respiratory | 4,882 (65.13%) | 1,442 (76.26%) | <0.001 | 917 (76.99%) | 525 (75.00%) | 0.353 |
Cardiovascular | 2,463 (32.85%) | 811 (42.88%) | <0.001 | 498 (41.81%) | 313 (44.71%) | 0.237 |
Renal | 2,211 (29.49%) | 608 (32.15%) | 0.026 | 374 (31.40%) | 234 (33.42%) | 0.389 |
Hematologic | 937 (12.50%) | 326 (17.23%) | <0.001 | 208 (17.46%) | 118 (16.85%) | 0.783 |
Metabolic | 693 (9.24%) | 221 (11.68%) | 0.001 | 139 (11.67%) | 82 (11.71%) | 1 |
Neurologic | 793 (10.57%) | 216 (11.42%) | 0.309 | 119 (9.99%) | 97 (13.85%) | 0.013 |
Hepatic | 731 (9.75%) | 214 (11.31%) | 0.047 | 117 (9.82%) | 97 (13.85%) | 0.009 |
Site of infection | ||||||
Respiratory | 1,775 (23.67%) | 900 (47.59%) | <0.001 | 620 (52.05%) | 280 (40.00%) | <0.001 |
Digestive | 950 (12.67%) | 219 (11.58%) | 0.281 | 102 (8.56%) | 117 (16.71%) | <0.001 |
Genitourinary | 275 (3.66%) | 80 (4.23%) | 1 | 61 (5.12%) | 19 (2.71%) | 0.016 |
Central nervous system | 75 (1.01%) | 79 (4.17%) | <0.001 | 50 (4.19%) | 29 (4.14%) | 1 |
Skin, soft tissue, or bone | 153 (2.04%) | 32 (1.69%) | 0.377 | 19 (1.59%) | 13 (1.85%) | 0.809 |
Circulatory | 77 (1.02%) | 17 (0.89%) | 0.710 | 13 (1.09%) | 4 (0.57%) | 0.365 |
Opportunistic infections | 1,428 (19.05%) | 931 (49.23%) | <0.001 | 645 (54.16%) | 286 (40.86%) | <0.001 |
Candidiasis (pulmonary or esophageal) | 78 (1.02%) | 82 (4.34%) | <0.001 | 59 (4.95%) | 23 (3.29%) | 0.109 |
Cryptococcosis (extrapulmonary) | 1 (0.01%) | 27 (1.43%) | <0.001 | 18 (1.51%) | 9 (1.29%) | 0.843 |
Cytomegalovirus (other than liver, spleen, or nodes) | 40 (0.53%) | 80 (4.23%) | <0.001 | 70 (5.88%) | 10 (1.43%) | <0.001 |
Mycobacterium tuberculosis | 76 (1.01%) | 82 (4.34%) | <0.001 | 60 (5.04%) | 22 (3.14%) | 0.066 |
Pneumocystis jirovecii pneumonia | 12 (0.16%) | 225 (11.90%) | <0.001 | 195 (16.37%) | 30 (4.29%) | <0.001 |
Pneumonia (bacterial), recurrent | 1,336 (17.82%) | 579 (30.62%) | <0.001 | 367 (30.81%) | 212 (30.29%) | 0.850 |
Toxoplasmosis of brain | 3 (0.04%) | 40 (2.12%) | <0.001 | 33 (2.77%) | 7 (1.00%) | 0.016 |