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Table 2 Summary of diagnoses related to severe sepsis and opportunistic infections in the intensive care unit from 2005 to 2010

From: Mortality of patients infected with HIV in the intensive care unit (2005 through 2010): significant role of chronic hepatitis C and severe sepsis

  2a: Non-HIV versus all HIV patients 2b: HIV versus HIV/HCV patients
Control group All-HIV group P value HIV group HIV/HCV group P value
Severe sepsis 2,954 (39.41%) 1,092 (57.75%) <0.001 711 (59.70%) 381 (54.43%) 0.028
Acute organ dysfunction       
 Respiratory 4,882 (65.13%) 1,442 (76.26%) <0.001 917 (76.99%) 525 (75.00%) 0.353
 Cardiovascular 2,463 (32.85%) 811 (42.88%) <0.001 498 (41.81%) 313 (44.71%) 0.237
 Renal 2,211 (29.49%) 608 (32.15%) 0.026 374 (31.40%) 234 (33.42%) 0.389
 Hematologic 937 (12.50%) 326 (17.23%) <0.001 208 (17.46%) 118 (16.85%) 0.783
 Metabolic 693 (9.24%) 221 (11.68%) 0.001 139 (11.67%) 82 (11.71%) 1
 Neurologic 793 (10.57%) 216 (11.42%) 0.309 119 (9.99%) 97 (13.85%) 0.013
 Hepatic 731 (9.75%) 214 (11.31%) 0.047 117 (9.82%) 97 (13.85%) 0.009
Site of infection       
 Respiratory 1,775 (23.67%) 900 (47.59%) <0.001 620 (52.05%) 280 (40.00%) <0.001
 Digestive 950 (12.67%) 219 (11.58%) 0.281 102 (8.56%) 117 (16.71%) <0.001
 Genitourinary 275 (3.66%) 80 (4.23%) 1 61 (5.12%) 19 (2.71%) 0.016
 Central nervous system 75 (1.01%) 79 (4.17%) <0.001 50 (4.19%) 29 (4.14%) 1
 Skin, soft tissue, or bone 153 (2.04%) 32 (1.69%) 0.377 19 (1.59%) 13 (1.85%) 0.809
 Circulatory 77 (1.02%) 17 (0.89%) 0.710 13 (1.09%) 4 (0.57%) 0.365
Opportunistic infections 1,428 (19.05%) 931 (49.23%) <0.001 645 (54.16%) 286 (40.86%) <0.001
 Candidiasis (pulmonary or esophageal) 78 (1.02%) 82 (4.34%) <0.001 59 (4.95%) 23 (3.29%) 0.109
 Cryptococcosis (extrapulmonary) 1 (0.01%) 27 (1.43%) <0.001 18 (1.51%) 9 (1.29%) 0.843
 Cytomegalovirus (other than liver, spleen, or nodes) 40 (0.53%) 80 (4.23%) <0.001 70 (5.88%) 10 (1.43%) <0.001
Mycobacterium tuberculosis 76 (1.01%) 82 (4.34%) <0.001 60 (5.04%) 22 (3.14%) 0.066
Pneumocystis jirovecii pneumonia 12 (0.16%) 225 (11.90%) <0.001 195 (16.37%) 30 (4.29%) <0.001
 Pneumonia (bacterial), recurrent 1,336 (17.82%) 579 (30.62%) <0.001 367 (30.81%) 212 (30.29%) 0.850
 Toxoplasmosis of brain 3 (0.04%) 40 (2.12%) <0.001 33 (2.77%) 7 (1.00%) 0.016
  1. Values are expressed as absolute number (percentage). P values were calculated by χ2 test, and P values in bold indicates statistically significant differences between groups. HCV, hepatitis C virus; HIV, human immunodeficiency virus.