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Table 3 Semiquantitative analysis of lung and diaphragm electron microscopy

From: Effects of sigh during pressure control and pressure support ventilation in pulmonary and extrapulmonary mild acute lung injury

Groups Lung Diaphragm
Alveolar-capillary membrane Type II epithelial cells Endothelial cells Abnormal myofibril with Z-disk edema Mitochondrial injury
ALIp PCV NS 2 (2-3) 3 (2.75-3) 2 (1.75-2.25) 3 (2.5-3) 2 (2-3)
Sigh 4 (3-4)* 3 (3-4) 3 (2.75-4)* 2 (2-3) 2 (2-2.5)
PSV NS 2 (1.75-2) 2 (2-2.25)* 1 (1-2) 2 (1.5-2)* 2 (1.5-2)
Sigh 2 (2-3)** 2 (2-2.25)** 2 (2-2)** 2 (1-2) 1(1-2)
ALIexp PCV NS 2 (1.75-2.25) 2 (1.75-2.25) 3 (2.75-3) 3 (2-3) 2 (2-3)
Sigh 2 (2-2.25) 3 (2-3)* 3 (2.75-3.25) 3 (2.5-3) 3 (2-3)
PSV NS 2 (1.75-2) 2 (1.75-2) 2 (1.75-2)* 2 (1.5-2) 2(1-2)
Sigh 3 (3-3.25)**# 3 (3-3.25)# 3 (3-4)# 2 (1.5-2) 2 (1.5-2)
  1. Values expressed as median (interquartile range) of five animals in each group. A five-point, semi-quantitative, severity-based scoring system was used. Pathological findings were graded as: 0 = normal lung parenchyma; 1 = changes in 1 to 25%; 2 = changes in 26 to 50%; 3 = changes in 51 to 75%; and 4 = changes in 76 to 100% of examined tissue. *Significantly different from PCV-NS (P <0.05); **significantly different from PCV-Sigh (P <0.05): #significantly different from PSV-NS (P <0.05). ALIp, pulmonary acute lung injury; PCV, pressure-controlled ventilation; NS, non-sigh; PSV, pressure support ventilation; ALIexp, extrapulmonary acute lung injury.