Effects of sigh during pressure control and pressure support ventilation in pulmonary and extrapulmonary mild acute lung injury

Table 3 Semiquantitative analysis of lung and diaphragm electron microscopy

Groups			Lung			Diaphragm
Groups			Alveolar-capillary membrane	Type II epithelial cells	Endothelial cells	Abnormal myofibril with Z-disk edema	Mitochondrial injury
ALIp	PCV	NS	2 (2-3)	3 (2.75-3)	2 (1.75-2.25)	3 (2.5-3)	2 (2-3)
	PCV	Sigh	4 (3-4)*	3 (3-4)	3 (2.75-4)*	2 (2-3)	2 (2-2.5)
	PSV	NS	2 (1.75-2)	2 (2-2.25)*	1 (1-2)	2 (1.5-2)*	2 (1.5-2)
	PSV	Sigh	2 (2-3)**	2 (2-2.25)**	2 (2-2)**	2 (1-2)	1(1-2)
ALIexp	PCV	NS	2 (1.75-2.25)	2 (1.75-2.25)	3 (2.75-3)	3 (2-3)	2 (2-3)
	PCV	Sigh	2 (2-2.25)	3 (2-3)*	3 (2.75-3.25)	3 (2.5-3)	3 (2-3)
	PSV	NS	2 (1.75-2)	2 (1.75-2)	2 (1.75-2)*	2 (1.5-2)	2(1-2)
	PSV	Sigh	3 (3-3.25)**^#	3 (3-3.25)^#	3 (3-4)^#	2 (1.5-2)	2 (1.5-2)

Values expressed as median (interquartile range) of five animals in each group. A five-point, semi-quantitative, severity-based scoring system was used. Pathological findings were graded as: 0 = normal lung parenchyma; 1 = changes in 1 to 25%; 2 = changes in 26 to 50%; 3 = changes in 51 to 75%; and 4 = changes in 76 to 100% of examined tissue. *Significantly different from PCV-NS (P <0.05); **significantly different from PCV-Sigh (P <0.05): ^#significantly different from PSV-NS (P <0.05). ALIp, pulmonary acute lung injury; PCV, pressure-controlled ventilation; NS, non-sigh; PSV, pressure support ventilation; ALIexp, extrapulmonary acute lung injury.

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