Table 1 Characteristics of the study patients and comparison between responders and nonresponders at baseline (before fluid challenge) a
Parameters | All patients | Responders | Nonresponders | P-value |
|---|---|---|---|---|
(N = 44) | (n = 26) | (n = 18) | ||
Age, yr | 58.5 (34.8 to 82.6) | 60.4 (36.0 to 84.2) | 51.4 (36.7 to 71.5) | 0.210 |
BMI | 23.6 (17.3 to 35.2) | 24.3 (17.6 to 40.0) | 22.6 (17.7 to 28.1) | 0.142 |
Females, n (%) | 18 (40) | 13 (30) | 5 (11) | 0.245 |
SAPS II | 67.5 (36.2 to 95.8) | 68.0 (39.6 to 87.3) | 62.5 (34.8 to 97.3) | 0.466 |
Norepinephrine, n (%) | 33 (75) | 20 (46) | 13 (30) | 1 |
Dose of norepinephrine, mg/h | 1.7 (0.0 to 5.7) | 1.3 (0.0 to 5.8) | 2.0 (0.0 to 5.6) | 0.91 |
Vt, ml/kg | 8.2 (6.4 to 11.0) | 8.4 (6.5 to 11.6) | 8.1 (6.1 to 9.7) | 0.315 |
Respiratory rate, breaths/min | 20 (15 to 26) | 20 (15 to 26) | 21 (16 to 26) | 0.293 |
PEEP, cmH2O | 7 (5 to 12) | 7 (5 to 11) | 7 (5 to 10) | 0.789 |
Pplat, cmH2O | 22 (15 to 27) | 23 (13 to 27) | 21 (16 to 27) | 0.801 |
ARDS, n (%) | 17 (39) | 7 (27) | 10 (56) | 0.06 |
ALI, n (%) | 12 (27) | 8 (31) | 4 (22) | 0.105 |
Laparotomy, n (%) | 10 (23) | 5 (19) | 5 (28) | 0.76 |
Origin of sepsis, n (%) | 0.88 | |||
Pulmonary | 19 (43) | 10 (39) | 9 (50) | |
Abdominal or urinary | 17 (39) | 10 (39) | 7 (39) | |
Skin | 5 (11) | 4 (15) | 1 (6) | |
Other | 3 (7) | 2 (8) | 1 (6) |