Figure 3
From: Silencing airway epithelial cell-derived hepcidin exacerbates sepsis-induced acute lung injury
The knockdown of hepcidin in airway epithelial cells worsened lung injury induced by cecal ligation and puncture (CLP) surgery. (A) Hematoxylin and eosin stain of lung tissue sections. A representative image is presented (magnification: ×400). n = 5 to 6 mice/group. (B) Lung wet/dry weight ratio. n = 5 to 6 mice/group. *P <0.05 versus Ad-shNeg-treated group. (C) Total cell counts in BALF. n = 5 to 6 mice/group. *P <0.05 versus Ad-shNeg-treated group. (D) BALF protein concentrations. n = 5 to 6 mice/group. *P <0.01 versus Ad-shNeg-treated group. (E) Bacterial counts in BALF. n = 5 to 6 mice/group. *P <0.05 versus Ad-shNeg-treated group. (F) IL-6 concentrations in BALF. n = 5 to 6 mice/group. (G) Survival rate was monitored for seven days. n = 16 mice in the Ad-shNeg + CLP and CLP groups, and n = 15 mice in the other groups. *P <0.05 versus Ad-shNeg-treated group.