Table 1 Evolution of biological parameters in the three groups
From: Hypertonic sodium lactate improves fluid balance and hemodynamics in porcine endotoxic shock
Time (T), minutes | 0.9% NaCl (NC) group | Hypertonic sodium bicarbonate (HSB) group | Hypertonic sodium lactate (HSL) group | P-value | |||
|---|---|---|---|---|---|---|---|
NC versus | NC versus | HSB versus | |||||
HSB | HSL | HSL | |||||
BLOOD | |||||||
Lactate, mmol/L | T0 | 0.7 (0.5 to 0.8) | 0.65 ( 0.6 to 0.7) | 0.7 (0.7 to 0.8) | ns | ns | ns |
T210 | 3.9 (2.7 to 6.9) | 3.7 (2.8 to 4.7) | 11.8 (10.5 to 17.7) | ns | 0.01 | 0.01 | |
T300 | 5.5 (3.8 to 8.0) | 4.2 (3.2 to 7.9) | 11.8 (10.3 to 16.0) | ns | 0.01 | 0.01 | |
pH | T0 | 7.45 (7.39 to 7.48) | 7.44 (7.38 to 7.47) | 7.43 (7.41 to 7.48) | ns | ns | ns |
T210 | 7.23 (7.21 to 7.26) | 7.45 (7.37 to 7.50) | 7.50 (7.46 to 7.53) | 0.01 | 0.01 | ns | |
T300 | 7.20 (7.17 to 7.24) | 7.47 (7.42 to 7.52) | 7.52 (7.47 to 7.55) | 0.01 | 0.01 | ns | |
HCO3 - , mmol/L | T0 | 29 ( 28 to 32) | 29 (28 to 31) | 30 (28 to 31) | ns | ns | ns |
T210 | 22 (20 to 26) | 48 (44 to 52) | 49 (46 to 54) | 0.01 | 0.01 | ns | |
T300 | 19 (15 to 25) | 54 (48 to 59) | 55 (51 to 58) | 0.01 | 0.01 | ns | |
PaCO2, mmHg | T0 | 43 (41 to 47) | 44 (40 to 49) | 45 (41 to 48) | ns | ns | ns |
T210 | 50 (44 to 53) | 65 (49 to 67) | 58 (49 to 63) | ns | ns | ns | |
T300 | 52 (47 to 59) | 70 (62 to 73) | 62 (57 to 68) | ns | ns | ns | |
Urea, g/L | T0 | 0.18 (0.13 to 0.21) | 0.16 (0.13 to 0.19) | 0.14 (0.11 to 0.20) | ns | ns | ns |
T300 | 0.34 (0.28 to 0.42) | 0.30 (0.26 to 0.34) | 0.18 (0.13 to 0.23) | ns | 0.02 | 0.02 | |
Creatinine, mg/L | T0 | 9.0 (7.5 to 10.0) | 7.0 (6.0 to 8.5) | 7.0 (6.5 to 8.5) | ns | ns | ns |
T300 | 16.0 (13.5 to 17.5) | 10.0 (9.5 to 14.5) | 11.0 (10.0 to 12.0) | 0.04 | 0.02 | ns | |
Na + , mmol/L | T0 | 140 (137 to 145) | 142 (138 to 146) | 137 (138 to 140) | ns | ns | ns |
T300 | 142 (138 to 146) | 164 (161 to 166) | 162 (158 to 164) | 0.01 | 0.01 | ns | |
K + , mmol/L | T0 | 4.0 (3.9 to 4.1) | 3.9 (3.5 to 4.3) | 3.9 (3.7 to 4.0) | ns | ns | ns |
T300 | 4.9 ( 4.6 to 5.4) | 3.7 (3.5 to 3.9) | 3.5 (3.3 to 3.6) | 0.01 | 0.01 | ns | |
Cl - , mmol/L | T0 | 101 (98 to 107) | 101 (100 to 105) | 100 (99 to 101) | ns | ns | ns |
T300 | 106 (103 to 115) | 98 (96 to 101) | 93 (91 to 96) | 0.02 | 0.01 | 0.02 | |
Ca2 + , mmol/L | T0 | 2.48 (2.37 to 2.51) | 2.55 (2.31 to 2.59) | 2.45 (2.37 to 2.57) | ns | ns | ns |
T300 | 2.1 (1.8 to 2.2) | 1.9 (1.8 to 2) | 2.0 (1.9 to 2.2) | ns | ns | ns | |
Mg2 + , mmol/L | T0 | 0.75 (0.70 to 0.80) | 0.68 (0.64 to 0.73) | 0.70 (0.68 to 0.77) | ns | ns | ns |
T300 | 1.0 (0.9 to 1.1) | 0.74 (0.66 to 0.88) | 0.70 (0.64 to 0.80) | 0.02 | 0.02 | ns | |
SID, mEq/L | T0 | 45 (42 to 47) | 44 (39 to 45) | 45 (44 to 46) | ns | ns | ns |
T300 | 36 (32 to 41) | 67 (60 to 70) | 64 (61 to 68) | 0.01 | 0.01 | ns | |
Osmolality, mosm/kg | T0 | 294 (289 to 304) | 290 (286 to 295) | 293 (286 to 296) | ns | ns | ns |
T300 | 302 (295 to 308) | 337 (335 to 342) | 341 (338 to 345) | 0.01 | 0.01 | ns | |
URINE | |||||||
Na + , mmol/L | T0 | 131 (78 to 150) | 91 (69 to 150) | 95 (84 to 110) | ns | ns | ns |
T300 | 111 (90 to 156) | 183 (169 to 190) | 0.03 | ||||
K + , mmol/L | T0 | 22.3 (16.6 to 38.6) | 15.3 (9.3 to 32.9) | 23.4 (13.6 to 28.8) | ns | ns | ns |
T300 | 24.6 (13.1 to 36.2) | 15.2 (10.7 to 17.9) | ns | ||||
Cl - , mmol/L | T0 | 157 (64 to 183) | 125 (64 to 197) | 98 (83 to 137) | ns | ns | ns |
T300 | 49 (31 to 55) | 51 (46 to 52) | ns | ||||
Osmolality, mosm/kg | T0 | 543 (309 to 683) | 475 (339 to 576) | 394 (252 to 468) | ns | ns | ns |
T300 | 366 (328 to 377) | 378 (362 to 383) | ns | ||||