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Table 1 Evolution of biological parameters in the three groups

From: Hypertonic sodium lactate improves fluid balance and hemodynamics in porcine endotoxic shock

  Time (T), minutes 0.9% NaCl (NC) group Hypertonic sodium bicarbonate (HSB) group Hypertonic sodium lactate (HSL) group P-value
NC versus NC versus HSB versus
HSB HSL HSL
BLOOD        
Lactate, mmol/L T0 0.7 (0.5 to 0.8) 0.65 ( 0.6 to 0.7) 0.7 (0.7 to 0.8) ns ns ns
  T210 3.9 (2.7 to 6.9) 3.7 (2.8 to 4.7) 11.8 (10.5 to 17.7) ns 0.01 0.01
  T300 5.5 (3.8 to 8.0) 4.2 (3.2 to 7.9) 11.8 (10.3 to 16.0) ns 0.01 0.01
pH T0 7.45 (7.39 to 7.48) 7.44 (7.38 to 7.47) 7.43 (7.41 to 7.48) ns ns ns
  T210 7.23 (7.21 to 7.26) 7.45 (7.37 to 7.50) 7.50 (7.46 to 7.53) 0.01 0.01 ns
  T300 7.20 (7.17 to 7.24) 7.47 (7.42 to 7.52) 7.52 (7.47 to 7.55) 0.01 0.01 ns
HCO3 - , mmol/L T0 29 ( 28 to 32) 29 (28 to 31) 30 (28 to 31) ns ns ns
  T210 22 (20 to 26) 48 (44 to 52) 49 (46 to 54) 0.01 0.01 ns
  T300 19 (15 to 25) 54 (48 to 59) 55 (51 to 58) 0.01 0.01 ns
PaCO2, mmHg T0 43 (41 to 47) 44 (40 to 49) 45 (41 to 48) ns ns ns
  T210 50 (44 to 53) 65 (49 to 67) 58 (49 to 63) ns ns ns
  T300 52 (47 to 59) 70 (62 to 73) 62 (57 to 68) ns ns ns
Urea, g/L T0 0.18 (0.13 to 0.21) 0.16 (0.13 to 0.19) 0.14 (0.11 to 0.20) ns ns ns
  T300 0.34 (0.28 to 0.42) 0.30 (0.26 to 0.34) 0.18 (0.13 to 0.23) ns 0.02 0.02
Creatinine, mg/L T0 9.0 (7.5 to 10.0) 7.0 (6.0 to 8.5) 7.0 (6.5 to 8.5) ns ns ns
  T300 16.0 (13.5 to 17.5) 10.0 (9.5 to 14.5) 11.0 (10.0 to 12.0) 0.04 0.02 ns
Na + , mmol/L T0 140 (137 to 145) 142 (138 to 146) 137 (138 to 140) ns ns ns
  T300 142 (138 to 146) 164 (161 to 166) 162 (158 to 164) 0.01 0.01 ns
K + , mmol/L T0 4.0 (3.9 to 4.1) 3.9 (3.5 to 4.3) 3.9 (3.7 to 4.0) ns ns ns
  T300 4.9 ( 4.6 to 5.4) 3.7 (3.5 to 3.9) 3.5 (3.3 to 3.6) 0.01 0.01 ns
Cl - , mmol/L T0 101 (98 to 107) 101 (100 to 105) 100 (99 to 101) ns ns ns
  T300 106 (103 to 115) 98 (96 to 101) 93 (91 to 96) 0.02 0.01 0.02
Ca2 + , mmol/L T0 2.48 (2.37 to 2.51) 2.55 (2.31 to 2.59) 2.45 (2.37 to 2.57) ns ns ns
  T300 2.1 (1.8 to 2.2) 1.9 (1.8 to 2) 2.0 (1.9 to 2.2) ns ns ns
Mg2 + , mmol/L T0 0.75 (0.70 to 0.80) 0.68 (0.64 to 0.73) 0.70 (0.68 to 0.77) ns ns ns
  T300 1.0 (0.9 to 1.1) 0.74 (0.66 to 0.88) 0.70 (0.64 to 0.80) 0.02 0.02 ns
SID, mEq/L T0 45 (42 to 47) 44 (39 to 45) 45 (44 to 46) ns ns ns
  T300 36 (32 to 41) 67 (60 to 70) 64 (61 to 68) 0.01 0.01 ns
Osmolality, mosm/kg T0 294 (289 to 304) 290 (286 to 295) 293 (286 to 296) ns ns ns
  T300 302 (295 to 308) 337 (335 to 342) 341 (338 to 345) 0.01 0.01 ns
URINE        
Na + , mmol/L T0 131 (78 to 150) 91 (69 to 150) 95 (84 to 110) ns ns ns
  T300   111 (90 to 156) 183 (169 to 190)    0.03
K + , mmol/L T0 22.3 (16.6 to 38.6) 15.3 (9.3 to 32.9) 23.4 (13.6 to 28.8) ns ns ns
  T300   24.6 (13.1 to 36.2) 15.2 (10.7 to 17.9)    ns
Cl - , mmol/L T0 157 (64 to 183) 125 (64 to 197) 98 (83 to 137) ns ns ns
  T300   49 (31 to 55) 51 (46 to 52)    ns
Osmolality, mosm/kg T0 543 (309 to 683) 475 (339 to 576) 394 (252 to 468) ns ns ns
  T300   366 (328 to 377) 378 (362 to 383)    ns
  1. Results are expressed as median with interquartile range. Mann-Whitney U-test was used for intergroup comparisons; P <0.05 was considered significant. Urine tests were not performed at 300 minutes in the NC group because all animals were anuric. SID, apparent strong ion difference ((Na+ + K+ + Ca2+ + Mg2+) – (Cl- + Lactate-)).