Table 1 Agents for which there is both positive benchtop evidence for class effect and reported clinical use associated with a positive outcome

 Local anaesthetics [11]-[14]

 Tricyclic antidepressants [9],[15]-[24]

 Doxepin

 Imipramine

 Amitriptyline

 Dothiepin

 Flecainide (benchtop model evidence equivocal)

 Propafenone

 Cocaine

Ca channel blockers [9],[25]-[27]

 Verapamil

 Diltiazem

Beta blockers [9],[28],[29]

 Propanolol

 Carvedilol

 Nebivolol

Miscellaneous [30],[31]

 Haloperidol