Table 2 Old and new β-lactamase inhibitors and specific activity against different classes of β-lactamases
Inhibitor | Class A | Class B | Class C | Class D | FDA Status |
|---|---|---|---|---|---|
Inhibitors with β-lactam structure |  |  |  |  |  |
   Clavulanic acid | ++ | - | + | + | Approved |
   Tazobactam | ++ | - | + | + | Approved |
   Sulbactam | ++ | - | + | + | Approved |
   BLI-489 | ++ | UA | ++ | ++ | Pre-clinical |
   Ro 48-1220 | +++ | UA | ++ | UA | Pre-clinical |
   4-phenyl cyclic phosphate | +++ | UA | ++ | UA | Pre-clinical |
   C3-methylene-modified group penicillin sulfone | UA | UA | ++ | UA | Pre-clinical |
   BAL 30376 | UA | + | ++ | UA | Pre-clinical |
   LK-157 | ++ | UA | UA | UA | Pre-clinical |
   Oxapenems | ++ | UA | ++ | ++ | Pre-clinical |
Inhibitors without β-lactam structure |  |  |  |  |  |
   NXL104 | +++ | + | ++ | ++ | Phase II |
   ME1071 | UA | ++ | UA | UA | Pre-clinical |