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Table 2 Old and new β-lactamase inhibitors and specific activity against different classes of β-lactamases

From: New treatment options against gram-negative organisms

Inhibitor Class A Class B Class C Class D FDA Status
Inhibitors with β-lactam structure      
   Clavulanic acid ++ - + + Approved
   Tazobactam ++ - + + Approved
   Sulbactam ++ - + + Approved
   BLI-489 ++ UA ++ ++ Pre-clinical
   Ro 48-1220 +++ UA ++ UA Pre-clinical
   4-phenyl cyclic phosphate +++ UA ++ UA Pre-clinical
   C3-methylene-modified group penicillin sulfone UA UA ++ UA Pre-clinical
   BAL 30376 UA + ++ UA Pre-clinical
   LK-157 ++ UA UA UA Pre-clinical
   Oxapenems ++ UA ++ ++ Pre-clinical
Inhibitors without β-lactam structure      
   NXL104 +++ + ++ ++ Phase II
   ME1071 UA ++ UA UA Pre-clinical
  1. UA, unknown activity; FDA: Food and Drug Administration