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Table 1 Differential diagnosis of thrombocytopenia in the ICU

From: Heparin-induced thrombocytopenia in the ICU: an overview

Sepsis and healthcare-associated infections
Drug-induced thrombocytopenia: e.g., GP IIb/IIIa inhibitor, thrombolytic agents, and antibiotics (e.g., vancomycin)
Perioperative fluid resuscitation
Disseminated intravascular coagulation (DIC)
Massive transfusion
Intravascular devices: ECMO, IABP, LVAD and pulmonary catheter
Liver disease/hypersplenism
Pulmonary embolism
Immune thrombocytopenias
Diabetic ketoacidosis
Cancer-associated DIC, primary bone marrow disorder
Antiphospholipid syndrome and systemic lupus erythematosis
EDTA-induced pseudothrombocytopenia
  1. ECMO: extracorporeal membrane oxygenation; IABP: intra-aortic balloon pump; LVAD: left ventricular assist device; EDTA: ethylenediaminetetraacetic acid