From: Long-term outcome in medical patients aged 80 or over following admission to an intensive care unit
All patients | Hospital survivors | Hospital non-survivors | HR univariate [95% CI] | Punivariate | Adjusted HR [95% CI] | Pmultivariate | |
---|---|---|---|---|---|---|---|
Number | 299 | 133 | 166 | ||||
Age in years, mean ± SD | 84 ± 4 | 84 ± 4 | 84 ± 4 | 1.02 [0.98; 1.06] | 0.35 | ||
Males | 140 (47) | 58 (44) | 82 (49) | 0.90 [0.66; 1.22] | 0.51 | ||
Mechanically ventilated | 176 (59) | 48 (36) | 128 (77) | 2.38 [1.65; 3.43] | <0.001 | ||
Renal replacement therapy | 21 (7) | 2 (1) | 19 (11) | 1.54 [0.95; 2.49] | 0.08 | ||
SAPS II, mean ± SD | 52 ± 22 | 42 ± 13 | 61 ± 24 | 1.04 [1.03;1.05] | <0.001 | 1.03 [1.03; 1.04] | <0.001 |
SOFA score, mean ± SDa | 7 ± 4 | 4 ± 3 | 8 ± 4 | 1.18 [1.14; 1.23] | <0.001 | ||
McCabe score | <0.001 | <0.001 | |||||
No fatal disease | 129 (43) | 69 (52) | 60 (36) | 1 | |||
Fatal disease at 5 years | 117 (39) | 53 (40) | 64 (39) | 1.28 [0.90; 1.83] | 0.17 | 1.40 [0.97; 2.02] | 0.07b |
Fatal disease at 1 year | 53 (18) | 11 (8) | 42 (25) | 2.66 [1.78; 3.96] | <0.001 | 3.17 [2.08; 4.83] | <0.001b |
Knaus score | 0.04 | ||||||
No limitation | 45 (15) | 27 (20) | 18 (11) | 1 | |||
Slight limitation | 121 (41) | 53 (40) | 68 (41) | 1.51 [0.89; 2.54] | 0.12 | ||
Severe limitation | 103 (34) | 42 (32) | 61 (37) | 1.61 [0.95; 2.73] | 0.08 | ||
Bedridden | 30 (10) | 11 (8) | 19 (11) | 2.55 [1.33; 4.87] | 0.004 | ||
Karnofsky score, median (IQR) | 80 (50-90) | 80 (60-90) | 80 (50-90) | 0.99 [0.98; 0.99] | 0.03 | ||
Nosocomial pneumonia | 30 (10) | 7 (5) | 23 (14) | 0.77 [0.49; 1.22] | 0.27 | ||
Treatment limitationc | 69 (23) | 25 (19) | 44 (26) | 1.38 [0.80-2.05] | 0.15 | ||
Admission diagnosis | <0.001 | 0.009 | |||||
Respiratory | 141 (47) | 71 (53) | 70 (42) | 0.77 [0.51; 1.16] | 0.21 | 0.88 [0.57; 1.34] | 0.54 |
Coma or neurological | 56 (19) | 22 (17) | 34 (20) | 1.23 [0.77; 1.98] | 0.39 | 0.97 [0.59; 1.58] | 0.91 |
Cardiac | 43 (14) | 10 (8) | 33 (20) | 3.04 [1.87; 4.9] | <0.001 | 2.28 [1.38; 3.77] | <0.001 |
Sepsis | 29 (10) | 12 (9) | 17 (10) | 1.48 [0.83; 2.6] | 0.19 | 1.32 [0.74; 2.38] | 0.35 |
Digestive | 17 (6) | 11 (8) | 6 (4) | 0.38 [0.16; 0.90] | 0.029 | 0.56 [0.23; 1.35] | 0.19 |
Renal | 7 (2) | 3 (2) | 4 (2) | 0.74 [0.26; 2.12] | 0.58 | 0.46 [0.16; 1.33] | 0.15 |
Other | 6 (2) | 4 (2) | 2 (1) | 0.83 [0.20; 3.39] | 0.8 | 1.51 [0.37; 6.24] | 0.57 |