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Table 3 Included randomized controlled trials- weaning

From: Invasive ventilation modes in children: a systematic review and meta-analysis

Reference Study population Intervention/mode Outcome measures Level of evidence
    Duration of weaning (days)a Extubation failure rate Oxygenation  
Randolph and colleagues [15] 182 children (age 0 to 17 years) with weaning of ventilation support for more than 24 hours and who failed a test for extubation readiness on minimal PS Multicenter study (10 centers) to evaluate weaning protocols comparing VS (continuous automated adjustment of PS by the ventilator) (n = 59) and PS (adjustment by clinicians) (n = 61) with standard care (no protocol) (n = 59) PS: 1.6 (0.9 to 4.1); VS: 1.8 (1.0 to 3.2); no protocol: 2.0 (0.9 to 2.9) (P = 0.75) PS (15%), VS (24%); no protocol (17%) (P = 0.44). Male children more frequently failed extubation (OR = 7.86 95% CI = 2.36 to 26.2; P < 0.001) ND 1++
  1. aData presented as median (interquartile range). CI, confidence interval; ND, no data; OR, odds ratio; PS, pressure support; VS, volume support.