Table 1 Baseline characteristics of patients included (means ± standard deviation, range)
Variable | DAA 6 μg/kg/h | DAA 12 μg/kg/h | DAA 18 μg/kg/h | DAA 24 μg/kg/h | Placebo |
|---|---|---|---|---|---|
n | 6 | 9 | 9 | 8 | 15 |
Age (years) | 70.8 ± 4.4 (66.0 to 78.0) | 65.7 ± 8.9 (46.0 to 74.0) | 51.9 ± 16.5 (30.0 to 72.0) | 45.6 ± 22.6 (18.0 to 78.0) | 60.7 ± 21.9 (22.0 to 84.0) |
Sex (Female) | 3/6 | 3/9 | 5/9 | 3/8 | 11/15 |
Body weight (kg) | 76.0 ± 9.7 (60.0 to 85.0) | 93.9 ± 13.3 (79.0 to 120.0) | 85.2 ± 17.6 (66.0 to 114.0) | 86.4 ± 13.8 (62.0 to 104.0) | 85.7 ± 18.6 (50.0 to 113.0) |
Systolic blood pressure (mmHg) | 115.0 ± 15.8 (100.0 to 140.0) | 129.1 ± 20.4 (95.0 to 160.0) | 129.1 ± 30.7 (95.0 to 188.0) | 119.5 ± 16.7 (80.0 to 132.0) | 133.7 ± 25.4 (100.0 to 181.0) |
Diastolic blood pressure (mmHg) | 66.4 ± 10.4 (57.0 to 80.0) | 86.4 ± 17.5 (62.0 to 120.0) | 82.4 ± 12.7 (70.0 to 104.0) | 68.9 ± 12.0 (50.0 to 85.0) | 76.6 ± 14.3 (60.0 to 110.0) |
Highest heart rate (1/minute) | 83.5 ± 14.2 (60.0 to 100.0) | 95.2 ± 19.4 (80.0 to 140.0) | 94.4 ± 17.3 (75.0 to 127.0) | 105.4 ± 21.6 (70.0 to 130.0) | 106.6 ± 9.9 (95.0 to 130.0) |
Earlier PE | 1/6 | 2/9 | 0 | 1/8 | 0 |
Earlier DVT | 1/6 | 2/9 | 1/9 | 2/8 | 2/15 |
Earlier ischemic stroke | 1/6 | 1/9 | 0 | 0 | 3/15 |