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Table 2 Univariate and multivariable analysis: determinants associated with unplanned extubationa

From: Risk factors and outcomes after unplanned extubations on the ICU: a case-control study

  Univariate analysis Multivariable analysis
Variables OR (95% CI) P value OR (95% CI) P value
Sexb 1.9 (1.07-3.48) 0.03 1.8 (0.84-3.89) 0.13
Age (yr) 0.9 (0.98-1.01) 0.76 1.0 (0.97-1.03) 0.98
BMI (kg/m2) 1.1 (1.00-1.10) 0.04 1.0 (0.97-1.11) 0.26
Subunit ICUc   0.02   
   ICU subunit A 1.2 (0.62-2.41) 0.60 1.0 (0.38-2.42) 0.94
   ICU subunit B 2.2 (1.23-4.02) 0.01 2.6 (1.06-6.53) 0.04
Length of stay at time of UE (days)d 0.9 (0.97-1.00) 0.07 1.0 (0.93-0.99) 0.01
Sodium (mmol/L) at time of UE 1.0 (1.00-1.09) 0.05 1.0 (0.97-1.11) 0.26
Ramsay Sedation Scale score at time of UE   <0.01   <0.01
   1 Anxious/agitated 41.4 (4.84-354.05) <0.01 30.6 (3.18-294.20) <0.01
   2 Awake/cooperative 15.2 (1.96-117.89) <0.01 25.5 (2.99-216.96) <0.01
   3 Responds to commands only 6.4 (0.77-53.29) 0.09 7.0 (0.78-63.01) 0.08
   4 Brisk response to loud noise 3.0 (0.29-31.01) 0.34 1.4 (0.12-15.97) 0.79
   5 Sluggish response to loud noise 2.8 (0.29-26.59) 0.37 1.8 (0.17-18.42) 0.62
   6 No response (reference) 1.0 (reference) - 1.0 (reference) -
Clonidine use at time of UE 2.3 (0.97-5.33) 0.06 2.3 (0.67-7.56) 0.19
Haloperidol use at time of UE 2.1 (1.24-3.51) 0.01 1.6 (0.66-3.72) 0.31
Methadone use at time of UE 2.0 (1.07-3.65) 0.03 0.9 (0.39-2.46) 0.97
Midazolam use at time of UE 1.4 (0.83-2.31) 0.21 2.3 (1.01-5.18) 0.05
Other benzodiazepine use at time of UE (diazepam, lorazepam, oxazepam, temazepam) 1.5 (0.85-2.55) 0.16 1.1 (0.48-2.69) 0.77
  1. aOR, odds ratio; 95% CI, 95% confidence interval; BMI, body mass index; ICU, intensive care unit; UE, unplanned extubation; bReference category is female; cReference is ICU subunit C; dIndex time, sampling time for controls and time of UE for patients.