From: Debate: Transfusing to normal haemoglobin levels will not improve outcome
Restrictive transfusion | Liberal transfusion | Absolute difference | 95% | ||
---|---|---|---|---|---|
Complication* | strategy group (n [%]) | strategy group (n [%]) | between groups (%) | Confidence interval† | P |
Cardiac | 55 (13.2) | 88 (21.0) | 7.8 | 2.7 to 12.9 | <0.01 |
Myocardial infarction | 3 (0.7) | 12 (2.9) | 2.1 | - | 0.02 |
Pulmonary oedema | 22 (5.3) | 45 (10.7) | 5.5 | 1.8 to 9.1 | <0.01 |
Angina | 5 (1.2) | 9 (2.1) | 0.9 | - | 0.28 |
Cardiac arrest | 29 (6.9) | 33 (7.9) | 0.9 | -2.6 to 4.5 | 0.6 |
Pulmonary | 106 (25.4) | 122 (29.1) | 3.7 | -2.3 to 9.7 | 0.22 |
ARDS | 32 (7.7) | 48 (11.4) | 3.8 | -0.2 to 7.8 | 0.06 |
Pneumonia | 87 (20.8) | 86 (20.5) | -0.3 | -5.8 to 5.1 | 0.92 |
Infectious | 42 (10.1) | 50 (11.9) | 1.9 | -2.4 to 6.1 | 0.38 |
Bacteraemia | 30 (7.2) | 40 (9.5) | 2.3 | -1.4 to 6.1 | 0.22 |
Line sepsis | 21 (5.1) | 17 (4.0) | -1 | -3.8 to 1.8 | 0.5 |
Septic shock | 41(9.8) | 29(6.9) | -2.9 | -6.7 to 0.8 | 0.13 |
Haematological‡ | 10 (2.4) | 10 (2.4) | 0 | -2.1 to 2.1 | 1 |
Gastrointestinal§ | 13 (3.1) | 19 (4.5) | 1.4 | -1.2 to 4.0 | 0.28 |
Neurological¶ | 25 (6.0) | 33 (7.9) | 1.9 | -1.6 to 5.3 | 0.28 |
Shock** | 67 (16.0) | 55 (13.1) | -2.9 | -7.7 to 1.8 | 0.23 |
Any complication | 205 (49.0) | 228 (54.3) | 5.2 | -1.5 to 12.0 | 0.12 |